Higgins G A, Humphrey E W, Dwight R W, Roswit B, Lee L E, Keehn R J
Cancer. 1986 Jul 15;58(2):352-9. doi: 10.1002/1097-0142(19860715)58:2<352::aid-cncr2820580226>3.0.co;2-d.
In a prospective randomized trial, 361 male patients with histologically proven adenocarcinoma of the rectum, judged preoperatively to require abdominoperineal resection (APR), were treated by surgery alone or were given 3,150 rads of preoperative radiotherapy. Surgical resection was done on 320 patients, 262 having "curative" APR. Only moderate symptoms from radiotherapy were noted and postoperative complications and 30-day mortality were similar in both groups. Five-year survival for curative APR was the same in both groups (50% for both treated and control patients). The incidence of positive lymph nodes in the resected specimens was 35% in treated and 41% in controls. In the first preoperative radiotherapy trial conducted by the group, 5-year survival in patients undergoing "curative" APR was 47% in treated versus 34% in control groups. Additionally, the difference in positive lymph nodes in the resected specimens was substantially greater in the first trial (26% in treated versus 44% in controls).
在一项前瞻性随机试验中，361例经组织学证实为直肠癌的男性患者，术前判断需要行经腹会阴联合切除术（APR），这些患者要么仅接受手术治疗，要么接受3150拉德的术前放疗。320例患者接受了手术切除，其中262例行“根治性”APR。放疗仅出现中度症状，两组术后并发症和30天死亡率相似。两组“根治性”APR的5年生存率相同（治疗组和对照组患者均为50%）。切除标本中阳性淋巴结的发生率在治疗组为35%，在对照组为41%。在该研究小组进行的首次术前放疗试验中，接受“根治性”APR的患者5年生存率在治疗组为47%，在对照组为34%。此外，在首次试验中，切除标本中阳性淋巴结的差异要大得多（治疗组为26%，对照组为44%）。
