Kamada Shuhei, Noguchi Hiroki, Yamamoto Shota, Tamura Kou, Aoki Hidenori, Takeda Asuka, Uchishiba Maimi, Minato Saki, Arata Moeka, Arakaki Ryosuke, Inui Hiroaki, Kagawa Tomohiro, Kawakita Takako, Yoshida Atsuko, Mineda Ayuka, Yamamoto Yuri, Kinouchi Riyo, Yoshida Kanako, Kaji Takashi, Nishimura Masato, Iwasa Takeshi
Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Brain Behav Immun Health. 2024 Apr 9;38:100772. doi: 10.1016/j.bbih.2024.100772. eCollection 2024 Jul.
Polycystic ovary syndrome (PCOS) is associated with an increased risk of psychological distress as well as enhanced responses to psychosocial stress. Recently, it was hypothesized that PCOS patients may be at high risk of novel COVID-19 infections and worse clinical presentations during such infections. Here, we evaluated the effects of PCOS on stress responses to bacterial and viral mimetics using dihydrotestosterone-induced PCOS model rats. Lipopolysaccharide (LPS; a bacterial mimetic) or polyinosinic-polycytidylic acid (Poly-IC; a viral mimetic) was injected into PCOS model rats (PCOS) and non-PCOS rats (control), and the rats' stress responses were evaluated. In the PCOS group, the rats' anorectic and febrile responses to LPS injection were enhanced, whereas their anorectic and febrile responses to Poly-IC injection were unaltered. The PCOS group also exhibited greater changes in peripheral cytokine levels in response to LPS, but not Poly-IC. On the contrary, after the injection of Poly-IC depressed locomotor activity was more evident in the PCOS group, whereas no such changes were observed after LPS injection. These findings indicate that although the stress responses of PCOS model rats to infection may be enhanced, the patterns of change in stress responses and their underlying mechanisms may differ between bacterial and viral infections.
多囊卵巢综合征（PCOS）与心理困扰风险增加以及对心理社会压力的反应增强有关。最近，有人提出假设，PCOS患者可能在新型冠状病毒肺炎（COVID-19）感染中具有高风险，并且在此类感染期间临床表现更差。在此，我们使用二氢睾酮诱导的PCOS模型大鼠评估了PCOS对细菌和病毒模拟物应激反应的影响。将脂多糖（LPS；一种细菌模拟物）或聚肌苷酸-聚胞苷酸（Poly-IC；一种病毒模拟物）注射到PCOS模型大鼠（PCOS组）和非PCOS大鼠（对照组）体内，并评估大鼠的应激反应。在PCOS组中，大鼠对LPS注射的厌食和发热反应增强，而对Poly-IC注射的厌食和发热反应未改变。PCOS组对LPS反应时外周细胞因子水平的变化也更大，但对Poly-IC无此变化。相反，注射Poly-IC后，PCOS组的运动活动抑制更为明显，而注射LPS后未观察到此类变化。这些发现表明，尽管PCOS模型大鼠对感染的应激反应可能增强，但细菌和病毒感染之间应激反应的变化模式及其潜在机制可能不同。
