Zhao Yunfeng, Jalili Saman
Analysis and Testing Center, Yancheng Institute of Technology, Yancheng 224051, Jiangsu, China.
Department of Biomaterials Science and Technology, Isfahan University of Technology, Isfahan, Iran.
Int J Biol Macromol. 2022 May 15;207:666-682. doi: 10.1016/j.ijbiomac.2022.02.114. Epub 2022 Feb 23.
Skin is the largest organ in the body which plays different roles in maintaining hemostasis. Although this tissue has a high healing potential, severe skin wounds cannot heal without external interventions. Among various treatment strategies, tissue-engineered wound dressings have gained significant attention. In this regard, tremendous progress has been made in the field of tissue engineering to develop constructs with higher healing activities. Material selection and optimization are key factors in development of such dressings. Among different candidates, dextran-based wound dressings have been extensively studied. Dextran is a branched biological macromolecule which is composed of anhydroglucose monomers. Due to its excellent biocompatibility, biodegradability, non-toxicity, modifiable functional groups, and proven clinical safety, dextran has found application in wound healing research. In the current review, applications, challenges, and future perspectives of dextran-based wound dressings will be discussed.
皮肤是人体最大的器官，在维持止血过程中发挥着不同作用。尽管该组织具有很高的愈合潜力，但严重的皮肤伤口若无外部干预则无法愈合。在各种治疗策略中，组织工程伤口敷料已受到广泛关注。在这方面，组织工程领域已取得巨大进展，以开发具有更高愈合活性的构建体。材料选择和优化是此类敷料开发的关键因素。在不同的候选材料中，基于葡聚糖的伤口敷料已得到广泛研究。葡聚糖是一种由脱水葡萄糖单体组成的分支生物大分子。由于其优异的生物相容性、生物降解性、无毒性、可修饰的官能团以及已证实的临床安全性，葡聚糖已在伤口愈合研究中得到应用。在本综述中，将讨论基于葡聚糖的伤口敷料的应用、挑战和未来展望。
