新型冠状病毒肺炎神经生物学的新认识。
Emerging Knowledge of the Neurobiology of COVID-19.
机构信息
Institute of Psychiatry, Psychology and Neuroscience, King's College, 16 De Crespigny Park, SE5 8AF London.
East Lancashire Hospitals NHS Trust, Casterton Ave, Burnley, BB10 2PQ.
出版信息
Psychiatr Clin North Am. 2022 Mar;45(1):29-43. doi: 10.1016/j.psc.2021.11.001. Epub 2021 Nov 11.
Abstract
Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and "long COVID," which occurs in many patients with a milder acute COVID-19 illness.
摘要
许多 COVID-19 患者会出现急性或长期的神经精神并发症。这些并发症背后的神经生物学机制正在开始显现；然而，神经嗜性假说并没有得到临床数据的有力支持。对 SARS-CoV-2 的炎症反应可能是导致谵妄和其他常见急性神经精神表现的原因。血管异常，如内皮病变，导致中风和脑微出血，以及随之而来的神经精神后遗症。长期神经精神综合征分为 2 大类：发生在严重（住院）COVID-19 后的神经精神缺陷和“长 COVID”，许多患有轻度急性 COVID-19 疾病的患者都会出现这种情况。
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2
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3
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4
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