Richards A M, Nicholls M G, Espiner E A, Ikram H, Cullens M, Hinton D
Clin Exp Hypertens A. 1986;8(2):153-66. doi: 10.3109/10641968609074769.
In order to determine arterial pressure and vasoactive hormone relationships in normotensive man, we measured intra-arterial pressure continuously along with hourly venous hormone levels (renin, angiotensin II, aldosterone and catecholamines) for 24 hours in 5 healthy volunteers under standardized conditions. Mean 24-hour levels of intra-arterial pressure 106/63 +/- 5.4/4.9 mmHg were much lower than in patients with mild essential hypertension studied earlier. A common diurnal pattern was seen for plasma renin, angiotensin II, and catecholamines, with higher levels in the day time and lower levels at night. Aldosterone levels however, paralleled those of cortisol at night. Plasma norepinephrine levels showed close, positive correlations with arterial pressure in all volunteers. We conclude that the level of blood pressure as measured continuously over 24 hours is lower than might be expected from regular clinic recordings; that aldosterone regulation is contributed to by ACTH in the nocturnal hours; and that fluctuations in arterial pressure and sympathetic activity over 24 hours are closely coupled.
为了确定血压正常者的动脉压与血管活性激素之间的关系，我们在标准化条件下，对5名健康志愿者连续24小时测量动脉内压力，并每小时测定一次静脉激素水平（肾素、血管紧张素II、醛固酮和儿茶酚胺）。24小时平均动脉内压力水平为106/63±5.4/4.9 mmHg，远低于先前研究的轻度原发性高血压患者。血浆肾素、血管紧张素II和儿茶酚胺呈现出共同的昼夜模式，白天水平较高，夜间水平较低。然而，醛固酮水平在夜间与皮质醇水平平行。在所有志愿者中，血浆去甲肾上腺素水平与动脉压呈密切正相关。我们得出结论，连续24小时测量的血压水平低于常规门诊记录的预期值；夜间促肾上腺皮质激素对醛固酮调节有作用；24小时内动脉压和交感神经活动的波动紧密相关。
