Balin A K, Allen R G
Dermatol Clin. 1986 Jul;4(3):347-58.
The authors outline the progression of thought on the mechanism of the aging process, giving emphasis to environmental factors that influence genetic events. Discussion is limited to those theories that explain fundamental causes of aging and have a firm thermodynamic basis. The authors propose that the cumulative result of continual oxidative stress and other thermodynamic processes (such as amino-acid racemization and nonenzymatic glycosylation), resulting in altered function and increasing the net entropy of living systems, governs the rate of the aging process.
作者概述了关于衰老过程机制的思想发展，着重强调了影响基因事件的环境因素。讨论仅限于那些解释衰老根本原因且有坚实热力学基础的理论。作者提出，持续氧化应激和其他热力学过程（如氨基酸消旋化和非酶糖基化）的累积结果，导致功能改变并增加生物系统的净熵，从而决定了衰老过程的速率。
