Cohen S M, Olin K L, Feuer W J, Hjelmeland L, Keen C L, Morse L S
Department of Ophthalmology, University of California, Davis, Sacramento 95816.
Br J Ophthalmol. 1994 Oct;78(10):791-4. doi: 10.1136/bjo.78.10.791.
Age-related macular degeneration (ARMD) may result from events initiated by reactive oxygen species. Blood samples from 18 patients with ARMD and 18 similarly aged controls were analysed for activities of important antioxidants. Blood glutathione reductase activity was lower in patients with ARMD compared with controls (p = 0.035). The activities of glutathione peroxidase (p = 0.18) and erythrocyte superoxide dismutase (p = 0.29) were similar between the two groups by a Student's two sample t test. Logistic regression was used to determine which enzyme activities were associated with ARMD after adjusting for possible confounding variables: smoking history, age, multivitamin use, and cardiovascular disease. Glutathione reductase activity (p = 0.05) and glutathione peroxidase activity (p = 0.065) were significantly associated with ARMD by this analysis. The relation of glutathione reductase and glutathione peroxidase activity to ARMD merits further study.
年龄相关性黄斑变性（ARMD）可能由活性氧引发的事件导致。对18例ARMD患者和18例年龄相仿的对照者的血样进行了重要抗氧化剂活性分析。与对照组相比，ARMD患者的血液谷胱甘肽还原酶活性较低（p = 0.035）。通过学生双样本t检验，两组间谷胱甘肽过氧化物酶活性（p = 0.18）和红细胞超氧化物歧化酶活性（p = 0.29）相似。采用逻辑回归分析在调整可能的混杂变量（吸烟史、年龄、复合维生素使用情况和心血管疾病）后确定哪些酶活性与ARMD相关。通过该分析，谷胱甘肽还原酶活性（p = 0.05）和谷胱甘肽过氧化物酶活性（p = 0.065）与ARMD显著相关。谷胱甘肽还原酶和谷胱甘肽过氧化物酶活性与ARMD的关系值得进一步研究。
