Department of Urologic Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, No 1, East Banshan Road, Gongshu District, Hangzhou, 310022, People's Republic of China.
World J Surg Oncol. 2022 Feb 27;20(1):57. doi: 10.1186/s12957-022-02493-6.
Second primary renal cell carcinoma (2nd RCC) refers to renal cell carcinoma (RCC) diagnosed after another unrelated malignancy. This study aims to compare the clinical manifestation, pathology, treatment, and prognostic features of patients with 2nd RCC and first primary renal cell carcinoma (1st RCC).
Data of the patients with localized RCC were retrospectively collected. They were classified as 2nd RCC or 1st RCC according to a previously diagnosed cancer, including 113 cases of 2nd RCC and 749 cases of 1st RCC.
The most common types of extrarenal malignancies in patients with 2nd RCC include lung, colorectal, breast, gynecological, and gastric cancers. The age and smoking rate of 2nd RCC patients were significantly higher than in those of 1st RCC patients. For 2nd RCC patients, fewer had clinical symptoms and renal masses tend to be smaller. One hundred and eight (95.6%) patients with 2nd RCC received surgical interventions. All patients with 1st RCC underwent renal surgery. More patients with 2nd RCC underwent a partial nephrectomy. Pathologically, there was no significant difference in postoperative pathological types between the 2nd and 1st RCCs. However, the 2nd RCCs were commonly identified in the early stages. The median overall survival (OS) of 2nd RCC patients was 117 months, which was shorter than that of 1st RCC patients.
Second RCC is not uncommon. More attention should be paid to screening for 2nd RCC in cancer survivors. There are some differences between patients with 2nd and 1st RCCs that should be viewed separately.
第二原发肾细胞癌（2nd RCC）是指在另一种无关恶性肿瘤诊断后发生的肾细胞癌（RCC）。本研究旨在比较 2nd RCC 和首发性肾细胞癌（1st RCC）患者的临床表现、病理、治疗和预后特征。
回顾性收集局限性 RCC 患者的数据。根据既往诊断的癌症将其分为 2nd RCC 或 1st RCC，其中 2nd RCC 113 例，1st RCC 749 例。
2nd RCC 患者最常见的肾外恶性肿瘤类型包括肺癌、结直肠癌、乳腺癌、妇科和胃癌。2nd RCC 患者的年龄和吸烟率明显高于 1st RCC 患者。2nd RCC 患者的临床症状较少，肾脏肿块较小。108 例（95.6%）2nd RCC 患者接受了手术干预。所有 1st RCC 患者均接受了肾切除术。更多的 2nd RCC 患者接受了部分肾切除术。术后病理类型在 2nd 和 1st RCC 之间无显著差异。然而，2nd RCC 通常在早期被发现。2nd RCC 患者的中位总生存期（OS）为 117 个月，短于 1st RCC 患者。
2nd RCC 并不少见。癌症幸存者应更加注意筛查 2nd RCC。2nd 和 1st RCC 患者之间存在一些差异，应分别对待。
