Memiş Sadi
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.
J Korean Assoc Oral Maxillofac Surg. 2022 Feb 28;48(1):33-40. doi: 10.5125/jkaoms.2022.48.1.33.
Prolotherapy is a method that has gained popularity in recent years and has been reported to have positive short-term and long-term clinical results in maxillofacial surgery, especially temporomandibular joint (TMJ) hypermobility. This study aimed to evaluate the changes in the trabecular structure of mandibular condyles in patients who underwent prolotherapy due to TMJ hypermobility using the fractal analysis method.
Forty-five patients who received dextrose prolotherapy at a concentration of 20% and fifteen control patients were included in the study. All patients had panoramic radiographs just before (T0) and six months after treatment (T1). The patients who received treatment were divided into three groups according to the number of prolotherapy injections. The regions of interest were selected from bone areas close to the articular surfaces of the condyles. The fractal dimension (FD) values were calculated.
The main effect of time on the FD value was significant [F (1, 56)=86.176, <0.001]. This effect was qualified by a significant time×group interaction effect [F (3, 56)=9.023, <0.001]. The decreases in FD values in all treatment groups between T0 and T1 times were significant (=0.004). However, changes in FD values were not significant in the control group (=0.728).
Dextrose prolotherapy without the effect of the number of injections caused a decrease in FD values in the mandibular condyles over time.
注射疗法是近年来颇受欢迎的一种方法，据报道，其在颌面外科手术，尤其是颞下颌关节（TMJ）活动度过大方面具有积极的短期和长期临床效果。本研究旨在使用分形分析方法评估因TMJ活动度过大而接受注射疗法的患者下颌髁突小梁结构的变化。
本研究纳入了45例接受20%葡萄糖注射疗法的患者和15例对照患者。所有患者在治疗前（T0）和治疗后6个月（T1）均拍摄了全景X线片。接受治疗的患者根据注射疗法的注射次数分为三组。感兴趣区域选自髁突关节面附近的骨区域。计算分形维数（FD）值。
时间对FD值的主要影响显著[F(1,56)=86.176，P<0.001]。该效应通过显著的时间×组交互效应得到验证[F(3,56)=9.023，P<0.001]。所有治疗组在T0和T1时间之间FD值的降低均显著（P=0.004）。然而，对照组中FD值的变化不显著（P=0.728）。
无论注射次数多少，葡萄糖注射疗法都会使下颌髁突的FD值随时间降低。
