Bianchetti Angelo, Rozzini Renzo, Bianchetti Luca, Coccia Flaminia, Guerini Fabio, Trabucchi Marco
Medicine and Rehabilitation Department, Istituto Clinico S.Anna Hospital, Gruppo San Donato, Brescia, Italy.
Italian Association of Psychogeriatric (Associazione Italiana di Psicogeriatria -AIP), Brescia, Italy.
Curr Treat Options Neurol. 2022;24(1):1-15. doi: 10.1007/s11940-022-00706-7. Epub 2022 Feb 23.
This review discusses the complex relationship between COVID-19 and dementia and how the pandemic has affected the management of patients with dementia. This population resulted particularly susceptible to SARS-CoV-2 infection and its effects and also to the negative effects of the measures taken worldwide to control the spread of the virus.
Patients with dementia were at increased risk for COVID-19 compared to patients without dementia, and diagnosis of dementia represents an independent risk factor for hospitalization in COVID-19 patients. Mortality due to SARS-CoV2 infection in subjects with dementia is 2-5 times higher than in the general population. Cognitive impairment and delirium have been described in COVID-19 survivors. SARS-COV2 pandemic exacerbates the vulnerability of dementia patients and their caregivers, due to the morbidity and mortality from COVID-19, the indirect effects of the pandemic on the social supports, and the effects on healthcare system on which they depend.
The COVID-19 pandemic requires people with dementia to move from traditional models of health care to innovative models for home care, to support caregivers' burden, and to improve long term care.
本综述探讨了新型冠状病毒肺炎(COVID-19)与痴呆症之间的复杂关系,以及疫情如何影响痴呆症患者的管理。这一人群对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染及其影响尤为易感,同时也易受全球为控制病毒传播而采取的措施的负面影响。
与无痴呆症患者相比,痴呆症患者感染COVID-19的风险更高,痴呆症诊断是COVID-19患者住院的独立危险因素。痴呆症患者因SARS-CoV-2感染导致的死亡率比普通人群高2至5倍。在COVID-19幸存者中已出现认知障碍和谵妄。由于COVID-19导致的发病率和死亡率、疫情对社会支持的间接影响以及对其所依赖的医疗系统的影响,SARS-CoV-2大流行加剧了痴呆症患者及其照护者的脆弱性。
COVID-19大流行要求痴呆症患者从传统的医疗保健模式转向创新的居家护理模式,以减轻照护者的负担,并改善长期护理。