用于潜在磷酸根阴离子传感的6,6´-二氨基-2,2´-联吡啶甲胺配体的高效合成
Efficient Synthesis of 6,6´-Diamido-2,2´-dipicolylamine Ligands for Potential Phosphate Anion Sensing.
作者信息
Wang Shuai, Gong Lichong, Fakhri Georges El, Wang Junfeng
机构信息
Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, Massachusetts 02114, United States.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
出版信息
New J Chem. 2021 Sep 28;45(36):16833-16840. doi: 10.1039/d1nj03030b. Epub 2021 Aug 17.
Abstract
We report here the efficient synthesis of 6,6´-diamido-2,2´-dipicolylamines (DA-DPAs) which could be applied to phosphate anion sensing pre-formed metal complexes. The design was based on the retrosynthetic analysis. This strategy enabled us to achieve the functionalized DA-DPAs in satisfactory yields with high purity using the Boekelheide rearrangement. Meanwhile, all the intermediates could be easily purified by silica gel column chromatography.
摘要
我们在此报告6,6´-二酰胺基-2,2´-联吡啶甲胺（DA-DPAs）的高效合成方法，该化合物可用于磷酸根阴离子传感预制金属配合物。该设计基于逆合成分析。此策略使我们能够使用博克尔海德重排反应以令人满意的产率和高纯度获得功能化的DA-DPAs。同时，所有中间体都可以通过硅胶柱色谱轻松纯化。
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