一例由蜂王浆主要蜂王浆蛋白3引起的过敏反应及其与蜂巢的交叉反应
A Case of Anaphylaxis Caused by Major Royal Jelly Protein 3 of Royal Jelly and Its Cross-Reactivity with Honeycomb.
作者信息
Li Jun-Da, Cui Le, Xu Ying-Yang, Guan Kai
机构信息
Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing, People's Republic of China.
出版信息
J Asthma Allergy. 2021 Dec 22;14:1555-1557. doi: 10.2147/JAA.S346045. eCollection 2021.
PURPOSE
Royal jelly and honeycomb are commonly consumed in China, and anaphylaxis caused by ingestion of royal jelly is rare. To date, there is no report of anaphylaxis after ingestion of royal jelly in China. Its cross-reactivity with honeycomb is still unclear.
CASE REPORT
A 56-year-old Chinese female experienced two episodes of anaphylaxis within 1 hour after ingestion of royal jelly within one month. After avoiding royal jelly and other bee products, no anaphylactic reaction occurred again. The skin prick test and basophil activation test showed positive reactivity to royal jelly and honeycomb. In immunoblotting and immunoblotting inhibition tests, a 60 kDa protein was recognized in royal jelly and cross-reactivity with honeycomb. The mass spectrometry data revealed that the 62kDa protein belongs to major royal jelly protein 3.
CONCLUSION
Our data suggest that major royal jelly protein 3 of royal jelly is a main allergen that induces anaphylaxis and cross-reactivity with honeycomb. Therefore, the patient was allergic to royal jelly to avoid other bee products.
目的
蜂王浆和蜂巢在中国是常见的食用品，因摄入蜂王浆引起的过敏反应较为罕见。迄今为止，中国尚无摄入蜂王浆后发生过敏反应的报告。其与蜂巢的交叉反应性仍不明确。
病例报告
一名56岁的中国女性在一个月内两次在摄入蜂王浆后1小时内发生过敏反应。在避免食用蜂王浆和其他蜂产品后，未再发生过敏反应。皮肤点刺试验和嗜碱性粒细胞活化试验显示对蜂王浆和蜂巢呈阳性反应。在免疫印迹和免疫印迹抑制试验中，在蜂王浆中识别出一种60 kDa的蛋白质，且与蜂巢存在交叉反应。质谱数据显示，该62 kDa蛋白质属于主要蜂王浆蛋白3。
结论
我们的数据表明，蜂王浆中的主要蜂王浆蛋白3是诱发过敏反应并与蜂巢产生交叉反应的主要过敏原。因此，该患者对蜂王浆过敏，应避免食用其他蜂产品。
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