Saini Manpreet, Vamne Amrita, Kumar Vijay, Chandel M S
Biochemistry, Index Medical College, Hospital & Research Centre, Malwanchal University, Indore, IND.
Community Medicine, Phulo Jhano Medical College, Sido Kanhu Murmu University, Dumka, IND.
Cureus. 2022 Jan 23;14(1):e21506. doi: 10.7759/cureus.21506. eCollection 2022 Jan.
Chronic kidney disease (CKD) causes irreversible damage to the renal tissue resulting in decreased kidney function. It is known more for its morbidity than for its mortality as the deranged kidney functioning affects almost every organ system of the body. Dyslipidemia is one of the most common complications of chronic renal failure (CRF) reflected even in the early stages of CRF and usually parallels the deterioration in renal function. As a consequence, dyslipidemia as a risk factor in CKD progression should be explored and documented more. The aim of the study was to compare the pattern of lipid profile in CKD patients on conservative management with that of CKD patients on hemodialysis.
This is a cross-sectional observational study conducted in Lucknow, India, between January 2021 to May 2021 after considering inclusion and exclusion criteria. The lipid profile of 105 eligible patients was analyzed using an autoanalyzer. After generation of the proper template, data was entered in Microsoft Excel (Microsoft Corp., Redmond, Washington, United States) and analysis was done through SPSS for Windows, Version 16.0 (Released 2007, SPSS Inc., Chicago, United States).
There was a statistically significant decrease in high-density lipoprotein (HDL) and an increase in triglycerides (TG) and very-low-density lipoprotein (VLDL) levels in CKD patients on hemodialysis when compared with CKD patients on conservative management. As far as total cholesterol and low-density lipoprotein (LDL) levels are concerned, they were also significantly increased in CKD patients on hemodialysis than CKD patients on conservative management.
Dyslipidemia progresses with the stage of CKD, so early monitoring of lipid profile in CKD patients may help in decreasing the progression of the disease and, hence, mortality in CKD patients.
慢性肾脏病（CKD）会对肾组织造成不可逆的损害，导致肾功能下降。由于紊乱的肾功能几乎会影响身体的每个器官系统，所以它的发病率比死亡率更为人所知。血脂异常是慢性肾衰竭（CRF）最常见的并发症之一，甚至在CRF的早期阶段就有所体现，并且通常与肾功能恶化平行。因此，应更多地探索和记录血脂异常作为CKD进展的一个危险因素。本研究的目的是比较接受保守治疗的CKD患者与接受血液透析的CKD患者的血脂谱模式。
这是一项横断面观察性研究，于2021年1月至2021年5月在印度勒克瑙进行，研究前考虑了纳入和排除标准。使用自动分析仪分析了105例符合条件患者的血脂谱。生成合适的模板后，将数据输入到Microsoft Excel（微软公司，美国华盛顿州雷德蒙德）中，并通过SPSS for Windows 16.0版（2007年发布，SPSS公司，美国芝加哥）进行分析。
与接受保守治疗的CKD患者相比，接受血液透析的CKD患者的高密度脂蛋白（HDL）水平有统计学意义的降低，甘油三酯（TG）和极低密度脂蛋白（VLDL）水平升高。就总胆固醇和低密度脂蛋白（LDL）水平而言，接受血液透析的CKD患者也比接受保守治疗的CKD患者显著升高。
血脂异常随CKD的阶段而进展，因此对CKD患者早期监测血脂谱可能有助于降低疾病进展，从而降低CKD患者的死亡率。
