Tang Juan, Fan Li, Lv Chunlei, Wan Runjie, Liu Jianjian, Liu Xiaoyan
International Medical Services, Qilu Hospital of Shandong University, Jinan 250012, China.
Jinan Lixiaqu Municipal Center For Disease Control and Precention, Jinan 250100, China.
Iran J Public Health. 2021 Nov;50(11):2191-2201. doi: 10.18502/ijph.v50i11.7573.
We aimed to investigate the efficacy of Shenqi Jiangtang granules-assisted Western medicine in the treatment of gestational diabetes mellitus (GDM).
A total of 147 patients with GDM treated in Qilu Hospital of Shandong University from Jan 2018 to Apr 2019 were enrolled. They were randomly divided into traditional Chinese medicine (TCM) combined with Western medicine group, Western medicine group and control group. The control group was treated with exercise combined with diet therapy, and the Western medicine group was additionally treated with metformin tablets. The TCM combined with Western medicine group was additionally treated with Shenqi Jiangtang granules.
After treatment, the levels of 10 indicators in the three groups were lower than those before treatment ( < 0.05). These indicators were the lowest in the TCM combined with Western medicine group. However, high-density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) after treatment increased in the three groups compared with those before treatment ( < 0.05), which was the most obvious in the TCM combined with Western medicine group. After treatment, the number of patients with natural delivery in the TCM combined with Western medicine group was the largest. The incidences of complications in pregnant women, fetuses and newborns were the lowest in the TCM combined with Western medicine group.
Application of Shenqi Jiangtang granules-assisted Western medicine in patients with GDM can effectively control blood glucose and lipid levels, enhance antioxidant capacity, reduce the levels of inflammatory cytokines and decrease the incidence of adverse pregnancy outcomes.
我们旨在研究参芪降糖颗粒辅助西药治疗妊娠期糖尿病（GDM）的疗效。
选取2018年1月至2019年4月在山东大学齐鲁医院治疗的147例GDM患者。将他们随机分为中药联合西药组、西药组和对照组。对照组采用运动联合饮食疗法治疗，西药组加用二甲双胍片治疗。中药联合西药组加用参芪降糖颗粒治疗。
治疗后，三组10项指标水平均低于治疗前（P<0.05）。这些指标在中药联合西药组中最低。然而，治疗后三组的高密度脂蛋白胆固醇（HDL-C）、谷胱甘肽过氧化物酶（GSH-PX）和超氧化物歧化酶（SOD）水平均较治疗前升高（P<0.05），在中药联合西药组中最为明显。治疗后，中药联合西药组自然分娩的患者数量最多。中药联合西药组孕妇、胎儿及新生儿并发症的发生率最低。
参芪降糖颗粒辅助西药应用于GDM患者可有效控制血糖和血脂水平，增强抗氧化能力，降低炎症细胞因子水平，减少不良妊娠结局的发生率。
