Zhu Runjiu, Wan Haoyang, Yang Hong, Song Mingrui, Chai Yu, Yu Bin
Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Front Cell Dev Biol. 2022 Feb 9;10:841612. doi: 10.3389/fcell.2022.841612. eCollection 2022.
As the population of most nations have a large proportion of older individuals, there is an increase in the prevalence of osteoporosis. Consequently, scientists have focused their attention on the pathogenic mechanisms of osteoporosis. Owing to an increase in studies on cellular senescence in recent years, research has begun to focus on the function of the senescent microenvironment in osteoporosis. With chronic inflammation, senescent cells in the bone marrow secrete a series of factors known as senescence-associated secretory phenotype (SASP) factors, acting on their own or surrounding healthy cells and consequently exacerbating ageing.The components of the SASP may differ depending on the cause of osteoporosis. This review aimed to summarize the relationship between SASP factors and osteoporosis and suggest new insights into the mechanistic investigation of osteoporosis.
由于大多数国家的人口中老年人占比很大，骨质疏松症的患病率有所上升。因此，科学家们将注意力集中在骨质疏松症的致病机制上。近年来，随着对细胞衰老研究的增加，研究开始关注衰老微环境在骨质疏松症中的作用。在慢性炎症的情况下，骨髓中的衰老细胞会分泌一系列称为衰老相关分泌表型（SASP）因子的物质，这些因子会作用于自身或周围的健康细胞，从而加剧衰老。SASP的成分可能因骨质疏松症的病因不同而有所差异。本综述旨在总结SASP因子与骨质疏松症之间的关系，并为骨质疏松症的机制研究提供新的见解。
