Wang Bei, Xu Wen, Hu Chengyu, Liu Kai, Chen Jinlan, Guo Chong, Yuan Chengfu
College of Medical Science, China Three Gorges University, Yichang, Hubei 443001, PR China.
College of Traditional Chinese Medicine, China Three Gorges University, Yichang, Hubei 443001, PR China.
Genes Dis. 2020 Dec 2;9(2):325-333. doi: 10.1016/j.gendis.2020.11.016. eCollection 2022 Mar.
The frequency of human suffering from cancer is increasing annually across the globe. This has fueled numerous investigations aimed at the prevention and cure of various cancers. Long non-coding RNA (lncRNA) are known to play a crucial role in cancer. For instance, cancer susceptibility candidate 11 (CASC11), as one of the long non-coding RNAs, has been reported to be overexpressed in various tumors. This review elucidates the mechanism by which lncRNA CASC11 regulates tumors' biological processes and affirms its value as a therapeutic target for tumors. Through systematic analysis and review of relevant articles in PubMed, we revealed the pathophysiological mechanism of CASC11 on the tumor by regulating the biological processes of tumor such as proliferation, autophagy, apoptosis, thereby promoting tumor metastasis. We also revealed the regulatory pathways of CASC11 in different tumors, for instance by acting on a variety of microRNAs, oncogenic proteins, carcinogens, and transcription factors. Consequently, CASC11 regulates cancer proliferation, apoptosis, and invasion by altering the WNT/β-catenin signaling pathway and epithelial-mesenchymal transition (EMT). Furthermore, CASC11 expression has a high pertinence with clinical prognosis, suggesting that it is a potential marker for malignant tumors or a clinical adjuvant therapy in the future.
全球范围内，人类患癌的频率正逐年上升。这推动了旨在预防和治疗各种癌症的大量研究。已知长链非编码RNA（lncRNA）在癌症中发挥关键作用。例如，癌症易感性候选基因11（CASC11）作为长链非编码RNA之一，已被报道在各种肿瘤中过表达。这篇综述阐明了lncRNA CASC11调节肿瘤生物学过程的机制，并肯定了其作为肿瘤治疗靶点的价值。通过对PubMed中相关文章的系统分析和综述，我们揭示了CASC11通过调节肿瘤增殖、自噬、凋亡等生物学过程对肿瘤的病理生理机制，从而促进肿瘤转移。我们还揭示了CASC11在不同肿瘤中的调控途径，例如通过作用于多种微小RNA、致癌蛋白、致癌物和转录因子。因此，CASC11通过改变WNT/β-连环蛋白信号通路和上皮-间质转化（EMT）来调节癌症的增殖、凋亡和侵袭。此外，CASC11的表达与临床预后高度相关，表明它是未来恶性肿瘤的潜在标志物或临床辅助治疗手段。
