Ghafouri-Fard Soudeh, Harsij Atefeh, Hussen Bashdar Mahmud, Taheri Mohammad, Sharifi Guive
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Cell Dev Biol. 2023 Jun 23;11:1131199. doi: 10.3389/fcell.2023.1131199. eCollection 2023.
The long non-coding RNA (lncRNA) cancer susceptibility 11 (CASC11) is a newly identified lncRNA located on chromosome 8q24.21. The expression of lncRNA CASC11 has been found to be elevated in different cancer types and the prognosis of the tumor is inversely correlated with the high CASC11 expression. Moreover, lncRNA CASC11 has an oncogenic function in cancers. The biological characteristics of the tumors, such as proliferation, migration, invasion, autophagy, and apoptosis can be controlled by this lncRNA. In addition to interacting with miRNAs, proteins, transcription factors, and other molecules, the lncRNA CASC11 modulates signaling pathways including Wnt/β-catenin and epithelial-mesenchymal transition. In this review, we have summarized studies on the role of lncRNA CASC11 in the carcinogenesis from cell lines, , and clinical perspectives.
长链非编码RNA（lncRNA）癌症易感性11（CASC11）是一种新发现的位于8号染色体q24.21区域的lncRNA。研究发现，lncRNA CASC11在不同癌症类型中表达升高，且肿瘤预后与CASC11高表达呈负相关。此外，lncRNA CASC11在癌症中具有致癌功能。该lncRNA可调控肿瘤的生物学特性，如增殖、迁移、侵袭、自噬和凋亡。除了与微小RNA（miRNA）、蛋白质、转录因子和其他分子相互作用外，lncRNA CASC11还可调节包括Wnt/β-连环蛋白和上皮-间质转化在内的信号通路。在本综述中，我们从细胞系、动物模型和临床等角度总结了关于lncRNA CASC11在肿瘤发生中作用的研究。
