Zheng Lian, Guan Zhenjie, Xue Miaomiao
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.
Department of Stomatology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.
Am J Transl Res. 2021 Sep 15;13(9):10922-10932. eCollection 2021.
Long non-coding RNAs (lncRNAs) are non-coding RNAs more than 200 nucleotides in length. Although they do not encode proteins, lncRNAs can regulate gene expression at the transcriptional, post-transcriptional, and epigenetic levels. Emerging data show that lncRNAs are important for tumorigenesis and cancer progression. Cancer susceptibility candidate 11 () is a prominent lncRNA that is upregulated in various types of cancers. Moreover, its overexpression correlates with larger tumor size, more advanced cancer stages, cancer metastasis, and poor overall survival for most types of cancer. Functionally, the knockdown of CASC11 can inhibit cell proliferation, invasion, and migration, while enhancing apoptosis through its regulation of gene expression and signaling pathways and its interactions with functional proteins. Here, we discuss the identification, expression, and function of . Additionally, we discuss the potential roles of as a diagnostic biomarker, prognostic biomarker, and therapeutic target in various cancers.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的非编码RNA。尽管它们不编码蛋白质，但lncRNAs可在转录、转录后和表观遗传水平上调节基因表达。新出现的数据表明，lncRNAs对肿瘤发生和癌症进展很重要。癌症易感性候选基因11（CASC11）是一种在各种类型癌症中上调的显著lncRNA。此外，其过表达与大多数类型癌症的更大肿瘤大小、更晚期癌症阶段、癌症转移和较差的总生存率相关。在功能上，敲低CASC11可抑制细胞增殖、侵袭和迁移，同时通过其对基因表达和信号通路的调节以及与功能蛋白的相互作用增强细胞凋亡。在这里，我们讨论了CASC11的鉴定、表达和功能。此外，我们还讨论了CASC11作为各种癌症的诊断生物标志物、预后生物标志物和治疗靶点的潜在作用。
