Zhu Yinghuai, Prommana Parichat, Hosmane Narayan S, Coghi Paolo, Uthaipibull Chairat, Zhang Yingjun
State Key Laboratory of Anti-Infective Drug Development (NO 2015DQ780357), Sunshine Lake Pharma Co., Ltd., Songshan Lake Industrial Park, Dongguan 523871, China.
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Pathum Thai 12120, Thailand.
ACS Omega. 2022 Feb 9;7(7):5864-5869. doi: 10.1021/acsomega.1c05888. eCollection 2022 Feb 22.
Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B (OH) ), were characterized using H and B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated for their antimalarial activity against (3D7 strain) with an IC value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.
通过级联过程合成了羟基官能化的硼纳米颗粒（BNPs），随后进行溴化和水解反应。使用氢和硼核磁共振光谱、傅里叶变换红外（FT-IR）光谱、电感耦合等离子体发射光谱（ICP-OES）、透射电子显微镜（TEM）、动态光散射（DLS）和X射线光电子能谱（XPS）方法对这些官能化的BNPs（B(OH)）进行了表征。还评估了这些纳米颗粒对恶性疟原虫（3D7株）的抗疟活性，其半数抑制浓度（IC）值为0.0021μM，并且对 Uppsala 87恶性胶质瘤（U87MG）细胞系、恶性黑色素瘤A375细胞系、KB人口腔癌细胞系、大鼠皮质神经元细胞系和大鼠成纤维样滑膜细胞（FLS）细胞系显示出低毒性。
