Department of Ophthalmology, 175679Sakarya University Education and Research Hospital, Sakarya, Turkey.
Eur J Ophthalmol. 2022 Nov;32(6):3637-3643. doi: 10.1177/11206721221083465. Epub 2022 Feb 28.
To evaluate the serum inflammatory marker levels in serous macular detachment (SMD) secondary to diabetic macular edema (DME).
Patients with DME were divided into two groups according to the presence of SMD. Group 1 consisted of 40 patients with SMD, Group 2 consisted of 40 patients without SMD, and Group 3 consisted of 40 healthy subjects. Neutrophil and mean platelet volume (MPV) were obtained from blood samples. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the systemic immune inflammation index (SII) were calculated. In Group 1 and 2 sub-group analysis was done according to grade of diabetic retinopathy (DR) and the results were analyzed in these subgroups.
The neutrophils, MPV, NLR, and SII levels were significantly higher in Group 1 ( = 0.000, = 0.004, = 0.000, = 0.001, respectively). In subgroup analysis; the neutrophils, NLR, and SII levels were significantly higher in patients with proliferative DR ( = 0.044, = 0.046, = 0.046, respectively) and the SII levels were significantly higher in patients with severe nonproliferative DR in Group 1 ( = 0.039). The mean CMT values were 548.8 ± 138.3 µm in Group 1 and 420.1 ± 112.7 µm in Group 2. The CMT values were significantly higher in Group 1 (: 0.000). However, there was no significant correlation between the CMT values and the systemic inflamatuar markers levels (>0.05) in both of the groups.
NLR and SII levels were significantly higher in DME with SMD, especially in advanced cases. Elevated serum inflammatory markers might be associated with a higher incidence of SMD.
评估糖尿病性黄斑水肿（DME）继发浆液性黄斑脱离（SMD）患者血清炎症标志物水平。
根据是否存在 SMD，将 DME 患者分为两组。第 1 组包括 40 例 SMD 患者，第 2 组包括 40 例无 SMD 患者，第 3 组包括 40 例健康受试者。从血液样本中获取中性粒细胞和平均血小板体积（MPV）。计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SII）。在第 1 组和第 2 组中，根据糖尿病视网膜病变（DR）的程度进行亚组分析，并对这些亚组的结果进行分析。
第 1 组的中性粒细胞、MPV、NLR 和 SII 水平显著升高（ = 0.000， = 0.004， = 0.000， = 0.001，分别）。在亚组分析中，增殖性 DR 患者的中性粒细胞、NLR 和 SII 水平显著升高（ = 0.044， = 0.046， = 0.046，分别），第 1 组中严重非增殖性 DR 患者的 SII 水平显著升高（ = 0.039）。第 1 组的平均 CMT 值为 548.8 ± 138.3μm，第 2 组为 420.1 ± 112.7μm。第 1 组的 CMT 值显著升高（：0.000）。然而，在两组中，CMT 值与系统炎症标志物水平之间均无显著相关性（>0.05）。
DME 伴 SMD 患者的 NLR 和 SII 水平显著升高，尤其是在晚期病例中。血清炎症标志物升高可能与 SMD 的发生率增加有关。
