单核细胞/高密度脂蛋白比值和中性粒细胞/淋巴细胞比值在预测糖尿病性黄斑水肿和早期抗血管内皮生长因子治疗反应中的作用。
The Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response.
机构信息
Faculty of Medicine, Department of Ophthalmology, Cumhuriyet University, Sivas, Turkey.
Faculty of Medicine, Department of Endocrinology and Metabolism, Cumhuriyet University, Sivas, Turkey.
出版信息
Ocul Immunol Inflamm. 2022 May 19;30(4):901-906. doi: 10.1080/09273948.2020.1849739. Epub 2021 Feb 17.
PURPOSE
To determine the association of monocyte-to-high-density lipoprotein ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) with diabetic macular edema (DME) and early anti-VEGF treatment response.
MATERIAL METHODS
This was a retrospective and cross-sectional study conducted with 143 patients with diabetes mellitus (53 diabetic retinopathy with DME, 38 diabetic retinopathy without DME, and 52 without diabetic retinopathy).
RESULTS
13.9 was the best cutoff value to predict DME for MHR, and 2 was for NLR (59% and 75% sensitivity and 81% and 59% specificity, respectively). Logistic regression analysis showed that NLR≥2 and MHR≥13.9 were significantly associated with DME prediction. However, neither NLR≥2 nor MHR≥13.9 was associated with central retinal thickness(CRT) or best corrected visual acuity(BCVA) outcomes after anti-VEGF treatment. On the other hand, increased NLR was associated with inferior CRT outcomes.
CONCLUSION
MHR and NLR were simple and cost-effective biomarkers to predict DME. Moreover, higher NLR may contribute to poor CRT outcomes.
目的
探讨单核细胞与高密度脂蛋白比值（MHR）和中性粒细胞与淋巴细胞比值（NLR）与糖尿病黄斑水肿（DME）及早期抗血管内皮生长因子（VEGF）治疗反应的关系。
材料与方法
这是一项回顾性和横断面研究，共纳入 143 例糖尿病患者（53 例糖尿病性视网膜病变伴 DME，38 例糖尿病性视网膜病变不伴 DME，52 例无糖尿病性视网膜病变）。
结果
MHR 的最佳截断值为 13.9，预测 DME 的敏感度和特异度分别为 59%和 81%；NLR 的最佳截断值为 2，敏感度和特异度分别为 75%和 59%。Logistic 回归分析显示，NLR≥2 和 MHR≥13.9 与 DME 预测显著相关。然而，NLR≥2 或 MHR≥13.9 均与抗 VEGF 治疗后中心视网膜厚度（CRT）或最佳矫正视力（BCVA）结局无关。另一方面，较高的 NLR 与 CRT 结局较差相关。
结论
MHR 和 NLR 是预测 DME 的简单且具有成本效益的生物标志物。此外，较高的 NLR 可能与 CRT 结局较差有关。
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