蘑菇中的多糖 - 肽复合物通过调节lncRNA - miRNA - mRNA轴改善动脉粥样硬化。
The polysaccharide-peptide complex from mushroom ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis.
作者信息
Li Yuan, Miao Miao, Yin Fan, Shen Nuo, Yu Wen-Qian, Guo Shou-Dong
机构信息
Institute of Lipid Metabolism and Atherosclerosis, Innovative Drug Research Centre, School of Pharmacy, Weifang Medical University, Weifang 261053, China.
出版信息
Food Funct. 2022 Mar 21;13(6):3185-3197. doi: 10.1039/d1fo03285b.
An -glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of . Of importance, CMPS-80 significantly ameliorated formation of atherosclerotic lesions and plasma lipid profiles in apolipoprotein E-deficient mice. Integrated informatics analysis suggested that CMPS-80 can modulate multiple lncRNA-microRNA-mRNA axes. CMPS-80 has a potential application for prevention of hyperlipidemia and atherosclerosis.
一种α-糖苷多糖-肽复合物CMPS-80是从……的子实体中获得的。重要的是，CMPS-80显著改善了载脂蛋白E缺陷小鼠动脉粥样硬化病变的形成和血浆脂质谱。综合信息学分析表明，CMPS-80可以调节多个lncRNA- microRNA- mRNA轴。CMPS-80在预防高脂血症和动脉粥样硬化方面具有潜在的应用价值。
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