Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Department of Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Sci Rep. 2021 May 5;11(1):9642. doi: 10.1038/s41598-021-89133-3.
Glioma is an aggressive primary tumor of the brain with a poorly understood etiology. We studied the association of 4 human polyomaviruses (HPyV)-JC virus (JCV), BK virus (BKV), human polyomavirus 6 (HPyV6), and Merkel cell polyomavirus (MCPyV) with glioma risk within the Cancer Prevention Study II in the US (CPS-II) and the Janus Serum Bank in Norway. Cohort participants subsequently diagnosed with glioma from the CPS-II (n = 37) and Janus Serum Bank (n = 323), a median of 6.9 and 15.4 years after blood collection, respectively, were matched to individual controls on age, sex, and date of blood draw. Serum antibodies to the major viral capsid protein (VP1) were used to establish infection history for each polyomavirus. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. In the Janus Serum Bank, MCPyV infection was associated with a higher risk of glioma overall (OR: 1.56; 95% CI 1.10, 2.19). A modest, nonsignificant positive association with MCPyV infection was also observed in CPS-II (OR: 1.29; 95% CI 0.54, 3.08). In both cohorts, glioma risk was not significantly related to infection with JCV, BKV or HPyV6. The present study suggests that MCPyV infection may increase glioma risk.
神经胶质瘤是一种侵袭性的原发性脑肿瘤，其病因尚不清楚。我们研究了 4 种人类多瘤病毒（HPyV）-JC 病毒（JCV）、BK 病毒（BKV）、人类多瘤病毒 6（HPyV6）和 Merkel 细胞多瘤病毒（MCPyV）与美国癌症预防研究 II （CPS-II）和挪威雅努斯血清库中神经胶质瘤风险的关系。CPS-II 中随后被诊断为神经胶质瘤的队列参与者（n=37）和雅努斯血清库（n=323），分别在采血后中位数 6.9 年和 15.4 年被匹配到个体对照的年龄、性别和采血日期。血清中针对主要衣壳蛋白（VP1）的抗体用于确定每种多瘤病毒的感染史。使用条件逻辑回归估计比值比（OR）和 95%置信区间（CI）。在雅努斯血清库中，MCPyV 感染与总体神经胶质瘤风险增加相关（OR：1.56；95%CI 1.10，2.19）。在 CPS-II 中也观察到与 MCPyV 感染适度但无统计学意义的正相关（OR：1.29；95%CI 0.54，3.08）。在两个队列中，JCV、BKV 或 HPyV6 感染与神经胶质瘤风险均无显著相关性。本研究表明，MCPyV 感染可能增加神经胶质瘤的风险。
