Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Magn Reson Med. 2022 Jul;88(1):28-37. doi: 10.1002/mrm.29196. Epub 2022 Feb 28.
To integrate deuterium metabolic imaging (DMI) with clinical MRI through an interleaved MRI and DMI acquisition workflow. Interleaved MRI-DMI was enabled with hardware and pulse sequence modifications, and the performance was demonstrated using fluid-attenuated inversion recovery (FLAIR) MRI as an example.
Interleaved FLAIR-DMI was developed by interleaving the H excitation and acquisition time windows into the intrinsic delay periods presented in the FLAIR method. All H MR signals were up-converted to the H Larmor frequency using a custom-built hardware unit, which also achieved frequency and phase locking of the output signal in real-time. The interleaved measurements were compared with direct measurements both in phantom and in the human brain in vivo.
The interleaved MRI-DMI acquisition strategy allowed simultaneous detection of FLAIR MRI and DMI in the same scan time as a FLAIR-only MRI acquisition. Both phantom and in vivo data showed that the MR image quality, DMI sensitivity as well as information content were preserved using interleaved MRI-DMI.
The interleaved MRI-DMI technology can be used to extend clinical MRI protocols with DMI, thereby offering a metabolic component to the MR imaging contrasts without a penalty on patient comfort or scan time.
通过交错式 MRI 和 DMI 采集工作流程，将氘代谢成像（DMI）与临床 MRI 相结合。通过硬件和脉冲序列修改实现交错式 MRI-DMI，并以液体衰减反转恢复（FLAIR）MRI 为例展示其性能。
通过将 H 激发和采集时间窗口交错到 FLAIR 方法中呈现的固有延迟期内，开发了交错式 FLAIR-DMI。所有 H 磁共振信号都使用定制的硬件单元转换为 H 拉莫尔频率，该单元还实时实现了输出信号的频率和相位锁定。交错测量结果与在体模和人体大脑中的直接测量结果进行了比较。
交错式 MRI-DMI 采集策略允许在与仅进行 FLAIR MRI 采集相同的扫描时间内同时检测 FLAIR MRI 和 DMI。无论是在体模还是在体内数据中，都表明交错式 MRI-DMI 保留了磁共振图像质量、DMI 灵敏度以及信息含量。
交错式 MRI-DMI 技术可用于扩展临床 MRI 协议中的 DMI，从而在不影响患者舒适度或扫描时间的情况下为磁共振成像对比提供代谢成分。
