Lisbon's Psychiatric Hospitalar Centre, Avenida do Brasil 53, 1749, Lisbon, Portugal.
Legismente, Forensic Psychiatry and Psychology, Rua Conde de Redondo, nº 8 3º dt., 1150, Lisbon, Portugal.
CNS Drugs. 2022 Apr;36(4):315-325. doi: 10.1007/s40263-022-00906-4. Epub 2022 Feb 28.
Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.
精神分裂症的疗效维持在很大程度上取决于患者对精神药物治疗的依从性。当精神分裂症患者负责自己的治疗时，部分或不依从的情况很常见，通常会导致病情复发。当医护人员给患者使用长效注射抗精神病药时，可以确保其依从性，但出于各种原因，有些患者可能不同意接受治疗。长效注射的替代方法是使用监督下口服长效抗精神病药。这种方法可以确保患者遵守规定的治疗方案，而无需注射。为了适合每周一次的口服给药，抗精神病药需要具有足够长的作用持续时间，并且能够耐受高剂量。有证据表明，每周口服匹莫齐特或奋乃静治疗精神分裂症是有效且耐受良好的。其他可能适合每周一次口服给药的药物包括阿立哌唑、布瑞哌唑和卡利拉嗪。
