Friedli A, De Grandi P
J Gynecol Obstet Biol Reprod (Paris). 1986;15(2):215-21.
Single vaginal application of a suppository containing 10 mg of 9-deoxo-16-PGE2 3 hours prior to suction curettage in nulliparous women with gestational ages from 8 to 12 weeks resulted in significant cervical softening (p less than 0.0001), and facilitated additional instrumental dilatation when required. Moderate side effects occurred in the majority of treated patients, disappeared however with appropriate medication. This procedure may thus be considered as effective, safe and reliable.
在孕龄为8至12周的未生育女性中，于负压刮宫术前3小时经阴道单次应用含10毫克9-脱氧-16-前列腺素E2的栓剂，可导致宫颈显著软化（p<0.0001），并在需要时便于进行额外的器械扩张。大多数接受治疗的患者出现了中度副作用，但通过适当用药后消失。因此，该方法可被认为是有效、安全且可靠的。
