Somell C, Olund A
Contraception. 1986 Feb;33(2):189-94. doi: 10.1016/0010-7824(86)90084-3.
Forty nulliparous women were treated with vaginal suppositories containing Meteneprost (9-deoxo-16, 16-dimethyl-9-methylene PGE2) (Upjohn Co.) 10 mg or placebo prior to termination of first trimester pregnancy in a double-blind study. The suppository was inserted three hours before vacuum aspiration. The cervical diameter as measured by the size of the largest Hegar dilatator inserted without resistance was significantly larger in women treated with Meteneprost. The operative blood loss was also reduced in the Meteneprost group.
在一项双盲研究中，40名未生育的女性在终止妊娠的前三个月，被给予含有米替前列醇（9-脱氧-16,16-二甲基-9-亚甲基前列腺素E2）（美国优普强公司）10毫克的阴道栓剂或安慰剂。在真空吸引前3小时插入栓剂。用无阻力插入的最大海格扩张器的尺寸测量，接受米替前列醇治疗的女性宫颈直径明显更大。米替前列醇组的术中失血量也减少。
