Brügger D, Dreher E
Geburtshilfe Frauenheilkd. 1985 Aug;45(8):567-9. doi: 10.1055/s-2008-1036371.
In the double-blind study reported here the authors were able to confirm the time- and dose-related effect of dilatation of the cervix by means of the new prostaglandin-E2 derivative (9-deoxo-16, 16-dimethyl-9-methylene-PG-E2-potassium salt) as compared to placebo. In spite of the short preoperative duration of action of three hours it was observed that half of the patients treated with the prostaglandin derivative vomited once or several times. The authors therefore consider that administration of the prostaglandin vaginal suppository is only justified in cases with a high risk of cervical injury, and in primiparae undergoing termination under local anesthesia. In 38 patients termination was performed by means of direct cervicomyometrial analgesia. With one exception they approved of chemical dilatation of the cervix in spite of the side-effects, assuming that it would result in less intraoperative pain.
在本文报道的双盲研究中，与安慰剂相比，作者能够证实新型前列腺素 - E2衍生物（9 - 脱氧 - 16,16 - 二甲基 - 9 - 亚甲基 - PG - E2 - 钾盐）对宫颈扩张具有时间和剂量相关效应。尽管术前作用持续时间短至三小时，但观察到接受前列腺素衍生物治疗的患者中有一半呕吐了一次或几次。因此，作者认为，仅在宫颈损伤风险高的病例以及在局部麻醉下进行终止妊娠的初产妇中，使用前列腺素阴道栓剂才是合理的。在38例患者中，通过直接宫颈肌层镇痛进行终止妊娠。除一例例外，他们认可宫颈化学扩张，尽管有副作用，认为这会减少术中疼痛。
