Barrett-Bee K J, Lane A C, Turner R W
J Med Vet Mycol. 1986 Apr;24(2):155-60. doi: 10.1080/02681218680000221.
The anti-dermatophyte agent tolnaftate was compared with the allylamine antifungal compounds naftifine and terbinafine. Tolnaftate was shown to inhibit sterol biosynthesis at the level of squalene epoxidation and squalene was shown to accumulate in dermatophytes grown in its presence. Biochemical studies in whole and broken cells supported this conclusion and showed that the compound was active against squalene epoxidation in broken C. albicans cells, but was much less potent against whole cells. These results suggested there was a barrier to penetration in these yeasts.
将抗皮肤癣菌剂托萘酯与烯丙胺类抗真菌化合物萘替芬和特比萘芬进行了比较。结果表明，托萘酯在角鲨烯环氧化水平上抑制甾醇生物合成，并且在其存在下生长的皮肤癣菌中角鲨烯会积累。对完整细胞和破碎细胞的生化研究支持了这一结论，结果表明该化合物对破碎的白色念珠菌细胞中的角鲨烯环氧化有活性，但对完整细胞的活性要低得多。这些结果表明在这些酵母中存在渗透屏障。
