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肝活检证实原发性肝淀粉样变性,仅有黄疸为首发症状:尸检病例报告。

Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report.

机构信息

Department of Gastroenterology, Saiseikai Chuwa Hospital, Japan.

Department of Pathology, Saiseikai Chuwa Hospital, Japan.

出版信息

Intern Med. 2022 Oct 1;61(19):2877-2881. doi: 10.2169/internalmedicine.9189-21. Epub 2022 Feb 26.

Abstract

Amyloidosis causes various symptoms in many organs of the body, but amyloidosis that presents with liver damage alone has never been reported. We treated an 83-year-old man with amyloidosis who presented with liver damage alone. The liver damage in this patient was histologically proven to be liver amyloidosis. The administration of bortezomib and dexamethasone was not effective, so he rapidly died of liver failure. An aggressive liver biopsy should be considered when unexplained jaundice is observed.

摘要

淀粉样变性可导致全身多个器官出现各种症状,但单独出现肝损伤的淀粉样变性从未有过报道。我们治疗了一例仅表现为肝损伤的淀粉样变性 83 岁男性患者。该患者的肝损伤经组织学证实为肝淀粉样变性。硼替佐米和地塞米松治疗无效,因此他迅速死于肝功能衰竭。当出现不明原因的黄疸时,应考虑进行积极的肝活检。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e05c/9593147/91d6a0db3c76/1349-7235-61-2877-g001.jpg

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