原发性孤立性肝脏淀粉样变性：一例报告及概述
Primarily isolated hepatic involvement of amyloidosis: A case report and overview.
作者信息
Ye Lei, Shi Hui, Wu Hui-Min, Wang Fang-Yu
机构信息
Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
出版信息
Medicine (Baltimore). 2016 Dec;95(52):e5645. doi: 10.1097/MD.0000000000005645.
BACKGROUND
Amyloidosis is particularly difficult to diagnose because the signs and symptoms are subtle. Additionally, there are no specific imaging or laboratory tests, except histopathology. Although it is considered to be a systemic disorder, a small portion of cases may be localized.
INTRODUCTION OF THE CASE
A 54-year-old man presented with nonspecific symptoms (jaundice and back pruritus). Biochemical tests showed a high level of bilirubin and elevated serum tumor markers (CA19-9 and CA125). Routine imaging showed hepatomegaly without heterogeneous enhancement. Liver biopsy confirmed the diagnosis of hepatic amyloidosis. No cardiac or renal involvement was found. The patient accepted treatment involving oral chemotherapy.
CONCLUSION
A rare and unique presentation of hepatic amyloidosis was highlighted in this case.
背景
淀粉样变性特别难以诊断，因为其体征和症状不明显。此外，除了组织病理学检查外，没有特定的影像学或实验室检查方法。尽管它被认为是一种全身性疾病，但一小部分病例可能是局限性的。
病例介绍
一名54岁男性出现非特异性症状（黄疸和背部瘙痒）。生化检查显示胆红素水平高，血清肿瘤标志物（CA19-9和CA125）升高。常规影像学检查显示肝脏肿大，无不均匀强化。肝脏活检确诊为肝淀粉样变性。未发现心脏或肾脏受累。患者接受了口服化疗治疗。
结论
该病例突出了肝淀粉样变性一种罕见且独特的表现形式。
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