Bucholc Magda, Bauermeister Sarah, Kaur Daman, McClean Paula L, Todd Stephen
Cognitive Analytics Research Lab School of Computing Engineering & Intelligent Systems Ulster University Londonderry UK.
Department of Psychiatry University of Oxford Oxford UK.
Alzheimers Dement (N Y). 2022 Feb 22;8(1):e12248. doi: 10.1002/trc2.12248. eCollection 2022.
We assessed the association of self-reported hearing impairment and hearing aid use with cognitive decline and progression to mild cognitive impairment (MCI).
We used a large referral-based cohort of 4358 participants obtained from the National Alzheimer's Coordinating Center. The standard covariate-adjusted Cox proportional hazards model, the marginal structural Cox model with inverse probability weighting, standardized Kaplan-Meier curves, and linear mixed-effects models were applied to test the hypotheses.
Hearing impairment was associated with increased risk of MCI (standardized hazard ratio [HR] 2.58, 95% confidence interval [CI: 1.73 to 3.84], = .004) and an accelerated rate of cognitive decline (.001). Hearing aid users were less likely to develop MCI than hearing-impaired individuals who did not use a hearing aid (HR 0.47, 95% CI [0.29 to 0.74], = .001). No difference in risk of MCI was observed between individuals with normal hearing and hearing-impaired adults using hearing aids (HR 0.86, 95% CI [0.56 to 1.34], = .51).
Use of hearing aids may help mitigate cognitive decline associated with hearing loss.
我们评估了自我报告的听力障碍和助听器使用与认知功能下降以及进展为轻度认知障碍（MCI）之间的关联。
我们使用了一个基于转诊的大型队列，该队列由4358名参与者组成，数据来自国家阿尔茨海默病协调中心。应用标准的协变量调整Cox比例风险模型、具有逆概率加权的边际结构Cox模型、标准化的Kaplan-Meier曲线和线性混合效应模型来检验假设。
听力障碍与MCI风险增加相关（标准化风险比[HR]2.58，95%置信区间[CI：1.73至3.84]，P = 0.004）以及认知功能下降加速（P = 0.001）。与未使用助听器的听力障碍个体相比，使用助听器的人患MCI的可能性更小（HR 0.47，95% CI [0.29至0.74]，P = 0.001）。听力正常的个体与使用助听器的听力障碍成年人之间在MCI风险上未观察到差异（HR 0.86，95% CI [0.56至1.34]，P = 0.51）。
使用助听器可能有助于减轻与听力损失相关的认知功能下降。
