Wang Shangchu, Wu Shujun, Zhang Yawei, Chen Juan, Zhou Xihong
Changsha Xinjia Bio-Engineering Co., Ltd., Changsha, 410000, China.
Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Biol Trace Elem Res. 2023 Feb;201(2):720-727. doi: 10.1007/s12011-022-03174-x. Epub 2022 Mar 1.
An experiment was conducted to compare the effects of replacing inorganic trace minerals (ITM) with different levels of complex organic trace minerals (OTM) on the growth performance, oxidative status, and intestinal function of piglets. Weanling piglets were assigned to five groups: a control group fed a basal diet supplemented with inorganic trace minerals and the other four groups fed basal diets supplemented with different levels of OTMs. The results showed that diets supplemented with 50 ppm Fe, 30 ppm Zn, 15 ppm Mn, and 0.2 ppm Se from OTM (L-OTM), or with 75 ppm Fe, 45 ppm Zn, 22.5 ppm Mn, and 0.3 ppm Se from OTM (M-OTM) significantly decreased the diarrhea ratio in the piglets compared with those supplemented with 100 ppm Fe, 90 ppm Zn, 40 ppm Mn, and 0.4 ppm Se from ITM. Compared with those in the ITM group, the piglets in the M-OTM group had significantly higher serum CuZnSOD, MnSOD, and GSH-Px levels. Moreover, piglets in the L-OTM and M-OTM groups had higher Sod and Gpx gene expression than those in the ITM group. Additionally, piglets in the L-OTM and M-OTM groups had significantly higher villus height than those in the ITM group, and the M-OTM group piglets had lower serum diamine oxidase content and higher ileal ZO-1 and occludin protein expression levels than those in the ITM group. These results indicate that replacing dietary ITMs with OTMs could decrease diarrhea occurrence and improve the oxidative status and intestinal barrier function in weanling piglets.
进行了一项实验，以比较用不同水平的复合有机微量元素（OTM）替代无机微量元素（ITM）对仔猪生长性能、氧化状态和肠道功能的影响。断奶仔猪被分为五组：一组为对照组，饲喂补充有无机微量元素的基础日粮，其他四组饲喂补充有不同水平OTM的基础日粮。结果表明，与饲喂补充有100 ppm铁、90 ppm锌、40 ppm锰和0.4 ppm硒的ITM的仔猪相比，日粮中补充来自OTM的50 ppm铁、30 ppm锌、15 ppm锰和0.2 ppm硒（低水平OTM，L-OTM），或补充来自OTM的75 ppm铁、45 ppm锌、22.5 ppm锰和0.3 ppm硒（中等水平OTM，M-OTM），显著降低了仔猪的腹泻率。与ITM组相比，M-OTM组仔猪的血清铜锌超氧化物歧化酶（CuZnSOD）、锰超氧化物歧化酶（MnSOD）和谷胱甘肽过氧化物酶（GSH-Px）水平显著更高。此外，L-OTM组和M-OTM组仔猪的超氧化物歧化酶（Sod）和谷胱甘肽过氧化物酶（Gpx）基因表达高于ITM组。另外，L-OTM组和M-OTM组仔猪的绒毛高度显著高于ITM组，M-OTM组仔猪血清二胺氧化酶含量低于ITM组，回肠紧密连接蛋白1（ZO-1）和闭合蛋白表达水平高于ITM组。这些结果表明，用OTM替代日粮中的ITM可减少断奶仔猪腹泻的发生，并改善其氧化状态和肠道屏障功能。
