Department of Internal Medicine, Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Saudi J Kidney Dis Transpl. 2021 Jul-Aug;32(4):1013-1018. doi: 10.4103/1319-2442.338274.
Chronic kidney disease (CKD) is associated with a state of chronic inflammation which is responsible for many of the pathophysiological changes detected in these patients. Many studies have evaluated the effect of Ramadan fasting on renal function and cardiovascular morbidity in CKD patients, but the effect of Ramadan fasting on markers of chronic inflammation was not previously assessed. This study aimed to evaluate the effect of Ramadan fasting on some markers of chronic inflammation in CKD patients with estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m body surface area and not on dialysis. This was a pilot study that included 20 patients (8 males and 12 females), mean age 61.9 years with CKD (eGFR <60 mL/min/1.73 m body surface area not on dialysis) who fasted the whole lunar month of Ramadan. Complete blood count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), high-sensitive C-reactive protein (hs-CRP), serum creatinine (SCr), eGFR, serum albumin, body weight, body mass index (BMI), and body composition assessed by bioimpedance analysis were assessed before and after Ramadan fasting. Ramadan fasting was not associated with significant change of SCr (P = 0.132), eGFR (P = 0.097), serum albumin (P = 0.352), body weight (P = 0.445), BMI (P = 0.168), body fat (P = 0.979), visceral fat (P = 0.163), muscle mass (P = 0.662), or body water (P = 0.815). There was a statistically significant decrease of markers of chronic inflammation including NLR (P = 0.003), PLR (P = 0.005), and hs-CRP (P = 0.000) after Ramadan fasting. Ramadan fasting was associated with improvement of the state of chronic inflammation in CKD patients (eGFR below 60 mL/min/1.73 m body surface area). Ramadan fasting was not associated with a significant change of body composition or deterioration of renal function tests in CKD patients.
慢性肾脏病（CKD）与慢性炎症状态相关，这种状态是这些患者许多病理生理变化的原因。许多研究已经评估了斋月禁食对 CKD 患者肾功能和心血管发病率的影响，但之前没有评估斋月禁食对慢性炎症标志物的影响。本研究旨在评估斋月禁食对肾小球滤过率（eGFR）<60 mL/min/1.73 m 体表面积且未接受透析的 CKD 患者某些慢性炎症标志物的影响。这是一项纳入 20 例（8 名男性和 12 名女性）平均年龄 61.9 岁的 CKD（eGFR<60 mL/min/1.73 m 体表面积且未接受透析）患者的前瞻性研究，这些患者在整个斋月期间禁食。在斋月禁食前后评估了全血细胞计数、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、高敏 C 反应蛋白（hs-CRP）、血清肌酐（SCr）、eGFR、血清白蛋白、体重、体重指数（BMI）以及通过生物阻抗分析评估的身体成分。斋月禁食与 SCr（P=0.132）、eGFR（P=0.097）、血清白蛋白（P=0.352）、体重（P=0.445）、BMI（P=0.168）、体脂（P=0.979）、内脏脂肪（P=0.163）、肌肉质量（P=0.662）或身体水分（P=0.815）无显著变化相关。斋月禁食后，慢性炎症标志物包括 NLR（P=0.003）、PLR（P=0.005）和 hs-CRP（P=0.000）显著下降。斋月禁食与 CKD 患者慢性炎症状态的改善相关（eGFR<60 mL/min/1.73 m 体表面积）。斋月禁食与 CKD 患者的身体成分无显著变化或肾功能试验恶化无关。
