Mbarki Houda, Tazi Nada, Najdi Adil, Tachfouti Nabil, Arrayhani Mohamed, Sqalli Tarik
Department of Nephrology, Hassan II University Hospital, Fez, Morocco.
Saudi J Kidney Dis Transpl. 2015 Mar;26(2):320-4. doi: 10.4103/1319-2442.152494.
Fasting during Ramadan is prohibited when an individual's health is endangered. Little work has been published in this direction in patients with chronic kidney disease (CKD). We aimed to evaluate the impact of fasting during Ramadan on the renal function of patients with CKD, adjusting for the initial degree of renal impairment. We prospectively studied 60 patients with CKD (35 females; mean age 45.6 ± 15.8 years). All study patients were older than 15 years, being followed-up at the nephrology clinic for more than six months, having a stable CKD during the preceding six months and who had fasted during Ramadan the previous year. Patients who had a medical contra-indication for fasting were excluded from the study [severe or resistant arterial hypertension, insulin-requiring diabetes, acute renal failure (ARF), active renal disease, repetitive urolithiasis or terminal chronic renal failure]. Statistical analysis was performed in collaboration with the epidemiology lab at the Fez Medical School using the SPSS software version 17. Three of the study patients developed ARF in the first week and four of them at the end of the month of the study period. The risk of developing ARF was significantly higher for patients with baseline creatinine clearance of <60 mL/min/1.73 m 2 . However, the small sample size does not allow us to draw any firm conclusions on fasting during Ramadan in stable CKD patients. Studies on larger numbers of patients are recommended.
当个人健康受到威胁时，斋月期间禁食是被禁止的。在慢性肾脏病（CKD）患者中，在这方面发表的研究较少。我们旨在评估斋月期间禁食对CKD患者肾功能的影响，并对初始肾功能损害程度进行校正。我们前瞻性地研究了60例CKD患者（35例女性；平均年龄45.6±15.8岁）。所有研究患者年龄均超过15岁，在肾病门诊随访超过6个月，在前6个月内CKD病情稳定且前一年斋月期间禁食。有禁食医学禁忌证的患者被排除在研究之外[重度或顽固性动脉高血压、需胰岛素治疗的糖尿病、急性肾衰竭（ARF）、活动性肾病、复发性尿路结石或终末期慢性肾衰竭]。使用SPSS软件版本17与非斯医学院流行病学实验室合作进行统计分析。3例研究患者在研究期第一周发生ARF，4例在研究期当月末发生ARF。基线肌酐清除率<60 mL/min/1.73 m² 的患者发生ARF的风险显著更高。然而，样本量较小，我们无法就稳定CKD患者斋月期间禁食得出任何确凿结论。建议对更多患者进行研究。
