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在参加青少年大脑与认知发展研究的青少年中,双曲线贴现率与问题性饮酒风险的关系。

Hyperbolic discounting rates and risk for problematic alcohol use in youth enrolled in the Adolescent Brain and Cognitive Development study.

机构信息

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.

Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.

出版信息

Addict Biol. 2022 Mar;27(2):e13160. doi: 10.1111/adb.13160.

Abstract

Adolescence is the peak period for the emergence of substance use, which can lead to long-term psychosocial, occupational and interpersonal complications. Ongoing large-scale, longitudinal, consortium initiatives, such as the Adolescent Brain and Cognitive Development (ABCD) study, offer unprecedented opportunities to elucidate key risk factors for problematic substance use in a well-powered sample and to examine how changes in risk factors relate to symptoms across time. Delay discounting has been proposed as a putative risk marker for early substance-use initiation and other forms of psychopathology. However, the extent to which other factors (e.g., socio-economic status and cognitive ability) influence discounting behaviour in young adolescents is not well established. The present study leverages data from the ABCD study (n = 11 045) to assess associations between core demographic and familial variables and delay discounting in youth-operationalized using hyperbolic discounting rates (k)-before the onset of significant psychopathology. Model estimates revealed significant effects of individual difference factors (e.g., sex and socio-economic status) and alcohol risk status (based on family history) on delay discounting. No significant differences were observed in the primary sample when comparing the presence of parent drug problems or prenatal drug exposures. These effects will require replication in later waves of ABCD. Nonetheless, these results provide support for delay discounting as a potential risk marker for problematic alcohol use and demonstrate a relationship between key demographic variables and adolescent discounting behaviour. Further, these results provide an empirical baseline from which developmental trajectories of delay discounting and substance use may be tracked throughout future waves of ABCD.

摘要

青春期是物质使用出现的高峰期,这可能导致长期的社会心理、职业和人际关系并发症。正在进行的大规模、纵向、联盟倡议,如青少年大脑与认知发展(ABCD)研究,为在一个功能强大的样本中阐明物质使用问题的关键风险因素,并研究风险因素随时间的变化如何与症状相关,提供了前所未有的机会。延迟折扣已被提议作为早期物质使用开始和其他形式的精神病理学的潜在风险标志物。然而,其他因素(例如社会经济地位和认知能力)在多大程度上影响青少年的折扣行为尚不清楚。本研究利用 ABCD 研究的数据(n=11045)来评估核心人口统计学和家族变量与延迟折扣之间的关联,这些数据是在出现明显精神病理学之前,使用双曲线折扣率(k)在青少年中进行操作化的。模型估计显示,个体差异因素(例如性别和社会经济地位)和酒精风险状况(基于家族史)对延迟折扣有显著影响。在比较父母吸毒问题或产前药物暴露的主要样本中,没有观察到显著差异。这些效应需要在 ABCD 的后续波次中进行复制。尽管如此,这些结果为延迟折扣作为物质使用问题的潜在风险标志物提供了支持,并表明关键人口统计学变量与青少年折扣行为之间存在关系。此外,这些结果提供了一个经验基线,可在此基础上跟踪未来 ABCD 波次中延迟折扣和物质使用的发展轨迹。

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