Bounoua Nadia, Church Leah D, Matyi Melanie A, Rudoler Jeremy, Wieand Kaleigh, Spielberg Jeffrey M
Department of Psychology, University of Maryland, College Park, Maryland, United States of America.
Department of Psychological & Brain Sciences, University of Delaware, Newark, Delaware, United States of America.
PLoS One. 2023 Sep 27;18(9):e0291868. doi: 10.1371/journal.pone.0291868. eCollection 2023.
Delay discounting is a well-established risk factor for risky behaviors and the development of externalizing spectrum disorders. Building upon recent work that developed a novel cortical marker of delay discounting (C-DD) in adult samples, the objective of this study was to test whether the C-DD relates to delay discounting and subsequently externalizing pathology in adolescent samples. The current study used two samples: 9992 early adolescents participating in the ABCD study (Mage = 9.93 years old, 48.7% female), and 56 early adolescents recruited from the community (Mage = 12.27 years old, 55.4% female). Cortical thickness was estimated using the FreeSurfer standard pipeline, and the cortical marker of delay discounting (C-DD) was calculated based on procedures outlined by the initial validation study. All data are cross-sectional in nature. As expected, C-DD was positively related to delay discounting in the ABCD sample, even after accounting for age, biological sex, collection site and data quality indicators. Moreover, results showed that C-DD was discriminately associated with externalizing, but not internalizing, symptoms in both samples of young adolescents. Findings replicate those found in adult samples, suggestive that C-DD may be a useful neuroanatomical marker of youth delay discounting. Replication of findings in other samples will be needed to determine whether C-DD has translational relevance to understanding externalizing psychopathology in adolescent samples.
延迟折扣是危险行为和外化性谱系障碍发展的一个公认的风险因素。基于最近在成人样本中开发出一种新型延迟折扣皮质标记物（C-DD）的工作，本研究的目的是测试C-DD是否与青少年样本中的延迟折扣相关，以及是否随后与外化性病理学相关。本研究使用了两个样本：9992名参与青少年大脑认知发展（ABCD）研究的青少年（平均年龄 = 9.93岁，48.7%为女性），以及从社区招募的56名青少年（平均年龄 = 12.27岁，55.4%为女性）。使用FreeSurfer标准流程估计皮质厚度，并根据初始验证研究概述的程序计算延迟折扣的皮质标记物（C-DD）。所有数据本质上都是横断面数据。正如预期的那样，即使在考虑了年龄、生物学性别、采集地点和数据质量指标之后，C-DD在ABCD样本中仍与延迟折扣呈正相关。此外，结果表明，在两个青少年样本中，C-DD都与外化症状有显著关联，但与内化症状无关。研究结果重复了在成人样本中发现的结果，表明C-DD可能是青少年延迟折扣的一个有用的神经解剖学标记物。需要在其他样本中重复这些发现，以确定C-DD在理解青少年样本中的外化性精神病理学方面是否具有转化相关性。
