Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Br J Nutr. 2024 Feb 14;131(3):521-530. doi: 10.1017/S0007114523001903. Epub 2023 Sep 11.
Systemic inflammation may contribute to the initiation and progression of type 2 diabetes mellitus (T2DM) through diet and lifestyle. We examined the association of dietary inflammation score (DIS), lifestyle inflammation score (LIS) and dietary and lifestyle inflammation score (DLIS) with T2DM and cardiometabolic risk factors among Iranian adults. In this study, we identified and recruited 619 patients with T2DM and 2113 without T2DM from 35 to 75 years old men and women in the baseline phase of the Sabzevar Persian Cohort Study. Using a validated 115-item semi-quantitative FFQ, we calculated a 19-component DIS and a 3-component LIS weighted by circulating inflammation biomarkers. The DIS, LIS and DLIS associations with diabetes were assessed by multivariable logistic regression analysis. The average age of the participants was 48·29 (sd 8·53) (without T2DM: 47·66 (sd 8·42); with T2DM: 50·44 (sd 8·57)). Individuals in the highest compared with the lowest tertiles of DLIS (OR: 3·40; 95 % CI 2·65, 4·35; < 0·001), DIS (OR: 3·41; 95 % CI 2·66, 4·38; < 0·001) and LIS (OR: 1·15; 95 % CI 0·90, 1·46; = 0·521) had an increased risk of T2DM. For those in the highest relative to the lowest joint DIS and LIS tertiles, the results were OR: 3·37; 95 % CI 2·13, 5·32; < 0·001. No significant associations were found between DLIS and cardiometabolic risk factors, including blood pressure, liver enzymes and glycaemic and lipid profiles, except for waist circumference ( < 0·001) and waist-to-hip ratio ( = 0·010). A higher DIS and DLIS score was associated with a higher risk of T2DM, while the LIS score was not associated with T2DM risk.
系统炎症可能通过饮食和生活方式导致 2 型糖尿病（T2DM）的发生和发展。我们研究了饮食炎症评分（DIS）、生活方式炎症评分（LIS）和饮食与生活方式炎症评分（DLIS）与伊朗成年人 T2DM 和心血管代谢危险因素的关系。在这项研究中，我们在萨布泽瓦尔波斯裔队列研究的基线阶段，从 35 岁至 75 岁的男性和女性中确定并招募了 619 名 T2DM 患者和 2113 名非 T2DM 患者。我们使用经过验证的 115 项半定量 FFQ 计算了 19 个成分的 DIS 和 3 个成分的 LIS，这些成分由循环炎症生物标志物加权。多变量逻辑回归分析评估了 DIS、LIS 和 DLIS 与糖尿病的关系。参与者的平均年龄为 48.29（sd 8.53）（无 T2DM：47.66（sd 8.42）；有 T2DM：50.44（sd 8.57））。与 DLIS（OR：3.40；95%CI 2.65，4.35；<0.001）、DIS（OR：3.41；95%CI 2.66，4.38；<0.001）和 LIS（OR：1.15；95%CI 0.90，1.46；=0.521）最低三分位相比，最高三分位的个体发生 T2DM 的风险更高。对于那些处于相对较高的 DIS 和 LIS 联合三分位的个体，结果为 OR：3.37；95%CI 2.13，5.32；<0.001。DLIS 与血压、肝酶以及血糖和血脂谱等心血管代谢危险因素之间没有显著关联，除了腰围（<0.001）和腰臀比（=0.010）。较高的 DIS 和 DLIS 评分与 T2DM 风险增加相关，而 LIS 评分与 T2DM 风险无关。
