Department of Systems Design Engineering, University of Waterloo, Waterloo, Canada.
Ontario Institute for Cancer Research, Toronto, Canada.
Sci Rep. 2022 Mar 1;12(1):3376. doi: 10.1038/s41598-022-06872-7.
Prostate cancer (PCa) is the second most common cancer in men worldwide and the most frequently diagnosed cancer among men in more developed countries. The prognosis of PCa is excellent if detected at an early stage, making early screening crucial for detection and treatment. In recent years, a new form of diffusion magnetic resonance imaging called correlated diffusion imaging (CDI) was introduced, and preliminary results show promise as a screening tool for PCa. In the largest study of its kind, we investigate the relationship between PCa presence and a new variant of CDI we term synthetic correlated diffusion imaging (CDI[Formula: see text]), as well as its performance for PCa delineation compared to current standard MRI techniques [T2-weighted (T2w) imaging, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging] across a cohort of 200 patient cases. Statistical analyses reveal that hyperintensity in CDI[Formula: see text] is a strong indicator of PCa presence and achieves strong delineation of clinically significant cancerous tissue compared to T2w, DWI, and DCE. These results suggest that CDI[Formula: see text] hyperintensity may be a powerful biomarker for the presence of PCa, and may have a clinical impact as a diagnostic aid for improving PCa screening.
前列腺癌（PCa）是全球男性第二大常见癌症，也是较发达国家男性中最常见的癌症。如果在早期发现，PCa 的预后非常好，因此早期筛查对于检测和治疗至关重要。近年来，一种称为相关扩散成像（CDI）的新型扩散磁共振成像形式被引入，初步结果显示其作为 PCa 筛查工具具有潜力。在同类研究中规模最大的一项研究中，我们研究了 PCa 存在与我们称之为合成相关扩散成像（CDI[公式：见文本]）的 CDI 新变体之间的关系，以及与当前标准 MRI 技术（T2 加权成像（T2w）、扩散加权成像（DWI）和动态对比增强（DCE）成像）相比，该变体在 200 例患者队列中对 PCa 进行描绘的性能。统计分析表明，CDI[公式：见文本]中的高信号是 PCa 存在的强烈指标，与 T2w、DWI 和 DCE 相比，其对临床显著癌组织的描绘能力较强。这些结果表明，CDI[公式：见文本]中的高信号可能是 PCa 存在的有力生物标志物，并且可能具有临床影响，作为改善 PCa 筛查的诊断辅助工具。
