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埃塞俄比亚西南部新生儿出生缺陷的发生率和模式:一项回顾性研究。

Prevalence and patterns of birth defects among newborns in southwestern Ethiopia: a retrospective study.

机构信息

Department of Anatomy, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Department of Obstetrics and Gynecology, School of Medicine, Institute of Health, Jimma University, Jimma, Ethiopia.

出版信息

Pan Afr Med J. 2021 Dec 21;40:248. doi: 10.11604/pamj.2021.40.248.25286. eCollection 2021.

Abstract

INTRODUCTION

prenatal development could be considered normal or abnormal. Abnormal development occurs because of interference of normal development from genetic disorders, environmental factors, and multifactorial inheritances during the critical period of embryogenesis. The present study was aimed at evaluating the prevalence and patterns of birth defects among newborns in southwestern Ethiopia.

METHODS

institutions-based cross-sectional study design was conducted in six purposively selected hospitals in southwestern Ethiopia based on their caseload. The study included data's from 2011 to 2015, during which 45,951 deliveries were recorded. All records of births in the selected hospitals were screened from medical records to identify the presence and types of birth defects.

RESULTS

out of twenty-one different birth defects identified, nearly half of them belong to anencephaly and hydrocephalus. Five types of birth defects, namely: anencephaly (25.0%), hydrocephalus (24.6%), spina bifida (13.1%), meningomyelocele (7.1%), and umbilical hernia (4.8%) accounted for about three-fourths (75%) of all recorded birth defects. The prevalence rate of birth defects at birth was 55 per 10,000 births.

CONCLUSION

in the present study, the neural tube defects were identified to be the most prevalent. Nearly equal proportions of birth defects occurred among male and female newborns. The majority of the mothers who gave birth to newborns with birth defects were younger than 35 years. The high prevalence of birth defects revealed in this study call for the need to implement urgent prevention strategies including but not limited to the provision of sustained family planning, youth education and antenatal care services, and strict observation of rational medication use during pregnancy to curb the possible occurrences of the birth defect.

摘要

简介

产前发育可被视为正常或异常。异常发育是由于遗传疾病、环境因素和多因子遗传在胚胎发生的关键期对正常发育的干扰而发生的。本研究旨在评估埃塞俄比亚西南部新生儿出生缺陷的流行率和模式。

方法

在埃塞俄比亚西南部的六所选定医院进行了基于机构的横断面研究设计,这些医院是根据其病例数选择的。该研究包括 2011 年至 2015 年的数据,在此期间记录了 45951 次分娩。从选定医院的病历中筛选出所有出生记录,以确定出生缺陷的存在和类型。

结果

在所确定的二十一种不同的出生缺陷中,近一半属于无脑畸形和脑积水。五种类型的出生缺陷,即无脑畸形(25.0%)、脑积水(24.6%)、脊柱裂(13.1%)、脑膜脑膨出(7.1%)和脐疝(4.8%),约占所有记录的出生缺陷的四分之三(75%)。出生时出生缺陷的患病率为每 10000 例活产 55 例。

结论

在本研究中,神经管缺陷被确定为最常见的。男婴和女婴出生缺陷的比例相等。分娩有出生缺陷的新生儿的母亲大多数年龄小于 35 岁。本研究中揭示的高出生缺陷率表明,需要实施紧急预防策略,包括但不限于提供持续的计划生育、青年教育和产前保健服务,以及严格监测怀孕期间合理用药,以遏制出生缺陷的发生。

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