Toofan Firooz, Hosseini Seyed Mojtaba, Alimohammadzadeh Khalil, Jafari Mehrnoosh, Bahadori Mohammadkarim
Department of Health Services Management, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Educ Health Promot. 2021 Dec 31;10:460. doi: 10.4103/jehp.jehp_1589_20. eCollection 2021.
COVID-19 pandemic has spread all over the world. However, information regarding clinical characteristics and prognostic factors is scarce. The aim of this study was to explore the impact of preexistent chronic comorbid conditions and multimorbidity on risk of mortality in patients with COVID-19.
We designed a retrospective, cross-sectional, observational, single-center study. Data were analyzed from all consecutive patients diagnosed with COVID-19 who admitted in a pandemic hospital affiliated with Tabriz University of Medical Sciences, Tabriz, Iran, from February 20, 2020, to September 25, 2020. The independent effects of preexistent conditions were evaluated using multivariate logistic regression model.
A total of 2597 hospitalized patients with COVID-19 were included. At least one preexistent condition was observed in 36.5% of study population. Multivariate logistic regression analysis showed that older age, male sex, diabetes, cardiovascular disease, hypertension, cancer, chronic kidney diseases, liver diseases, and chronic obstructive pulmonary disease were associated with increased risk of mortality. In addition, the number of comorbidities was significantly associated with increased odds of mortality compared to no-comorbidity.
The results of this study suggest that patients with comorbidities have an increased risk of in-hospital mortality following COVID-19 infection.
新型冠状病毒肺炎疫情已蔓延至全球。然而，关于其临床特征和预后因素的信息却很匮乏。本研究旨在探讨既往慢性合并症和多种合并症对新型冠状病毒肺炎患者死亡风险的影响。
我们设计了一项回顾性、横断面、观察性单中心研究。分析了2020年2月20日至2020年9月25日期间在伊朗大不里士医科大学附属大流行医院收治的所有连续确诊为新型冠状病毒肺炎患者的数据。使用多因素逻辑回归模型评估既往疾病的独立影响。
共纳入2597例住院的新型冠状病毒肺炎患者。36.5%的研究人群存在至少一种既往疾病。多因素逻辑回归分析显示，年龄较大、男性、糖尿病、心血管疾病、高血压、癌症、慢性肾脏病、肝脏疾病和慢性阻塞性肺疾病与死亡风险增加相关。此外，与无合并症相比，合并症的数量与死亡几率增加显著相关。
本研究结果表明，合并症患者在新型冠状病毒肺炎感染后院内死亡风险增加。
