Department of Life, Public Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Public Health Unit, Avezzano-Sulmona-L'Aquila, 67100 L'Aquila, Italy.
Int J Environ Res Public Health. 2023 Feb 9;20(4):3079. doi: 10.3390/ijerph20043079.
The presence of multiple chronic diseases is associated with an increase in mortality when related to COVID-19 infection.
(i) to evaluate the association between the severity of the COVID-19 disease, defined as symptomatic hospitalized in prison or symptomatic hospitalized out of prison, and the presence of one or more comorbidities in two prisons in central Italy: L'Aquila and Sulmona; (ii) to describe the profiles of inmates using multiple correspondence analysis (MCA).
A database was created including age, gender and clinical variables. The database containing anonymized data was password-protected. The Kruskal-Wallis test was used to evaluate a possible association between diseases and the severity of COVID-19 stratified by age groups. We used MCA to describe a possible characteristic profile of inmates.
Our results show that in the 25-50-year-old age group (COVID-19-negative) in the L'Aquila prison, 19/62 (30.65%) were without comorbidity, 17/62 (27.42%) had 1-2 comorbidities and only 3.23% had >2 diseases. It is interesting to note that in the elderly group, the frequency of 1-2 or >2 pathologies was higher than in the younger group, and only 3/51 (5.88%) inmates did not have comorbidities and were COVID-19 negative ( = 0.008). The MCA identified the following profiles: the prison of L'Aquila showed a group of women over 60 with diabetes, cardiovascular and orthopedic problems, and hospitalized for COVID-19; the Sulmona prison presented a group of males over 60 with diabetes, cardiovascular, respiratory, urological, gastrointestinal and orthopedic problems, and hospitalized or symptomatic due to COVID-19.
our study has demonstrated and confirmed that advanced age and the presence of concomitant pathologies have played a significant role in the severity of the disease: symptomatic hospitalized in the prison; symptomatic hospitalized out of the prison.
患有多种慢性疾病与 COVID-19 感染相关的死亡率增加有关。
（i）评估在意大利中部的拉奎拉和苏尔莫纳两所监狱中，COVID-19 疾病的严重程度（定义为监狱内有症状住院或监狱外有症状住院）与一种或多种合并症之间的关联；（ii）使用多元对应分析（MCA）描述囚犯的特征。
创建了一个包含年龄、性别和临床变量的数据库。包含匿名数据的数据库受到密码保护。使用 Kruskal-Wallis 检验评估按年龄组分层的疾病与 COVID-19 严重程度之间可能的关联。我们使用 MCA 来描述囚犯的可能特征。
我们的结果表明，在拉奎拉监狱 25-50 岁年龄组（COVID-19 阴性）中，19/62（30.65%）无合并症，17/62（27.42%）有 1-2 种合并症，只有 3.23%有>2 种疾病。有趣的是，在老年组中，1-2 种或>2 种疾病的频率高于年轻组，只有 3/51（5.88%）的囚犯没有合并症且 COVID-19 阴性（=0.008）。MCA 确定了以下特征：拉奎拉监狱显示出一组 60 岁以上的女性，患有糖尿病、心血管和骨科问题，并因 COVID-19 住院；苏尔莫纳监狱显示出一组 60 岁以上的男性，患有糖尿病、心血管、呼吸、泌尿科、胃肠道和骨科问题，并因 COVID-19 住院或有症状。
我们的研究表明并证实，年龄较大和同时存在合并症在疾病的严重程度中发挥了重要作用：监狱内有症状住院；监狱外有症状住院。
