Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Department of Public Health Solutions, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Aust N Z J Psychiatry. 2023 Jan;57(1):82-92. doi: 10.1177/00048674221082519. Epub 2022 Mar 2.
The impacts of postnatal psychiatric disorders on different types of mental health problems in offspring are unclear. We investigated the prospective associations of maternal postnatal depression, and anxiety, with offspring depression, anxiety, psychotic-like experiences and Borderline Personality Disorder symptoms, in adolescence, and examined whether these were independent of each other.
Data were obtained from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Maternal postnatal depression and anxiety at 8 weeks were measured using the Edinburgh Postnatal Depression Scale and Crown-Crisp Index, respectively. Offspring mental health outcomes were measured at 10-13 years old, using a variety of questionnaire-based and interview assessments. Logistic regression analyses were used to assess the associations between maternal postnatal risk factors and offspring mental health, and path analysis was used to investigate the pathways of maternal postnatal factors to adolescent offspring outcomes.
Data were available for 14,054 mothers with information reported on postnatal depression and 13,892 on postnatal anxiety. Logistic regression analyses found significant associations between maternal postnatal depression and offspring anxiety at 10 years old (odds ratio = 1.039, 95% confidence interval = [1.005, 1.073], = 0.022) and between maternal postnatal anxiety and offspring psychotic experiences at 12/13 years old (odds ratio = 1.042, 95% confidence interval = [1.008, 1.077], = 0.016). These significant associations remained after applying path analyses, when we controlled for potential offspring psychopathological overlay.
These findings suggest that mothers with postnatal depression are more likely to have offspring with anxiety at 10 years old, and that mothers with postnatal anxiety are more likely to have offspring with psychotic experiences at 12/13 years old. Our findings suggest specific pathways in the association between postnatal anxiety/depression and offspring mental health and contribute to the importance of identifying mothers and their offspring with increased vulnerability to adverse outcomes resulting from postnatal mental health disorders.
产后精神障碍对后代不同类型心理健康问题的影响尚不清楚。我们调查了产后抑郁和焦虑母亲与青少年后代抑郁、焦虑、类精神病体验和边缘型人格障碍症状的前瞻性关联，并检验了它们之间是否相互独立。
数据来自阿冯纵向父母与子女研究（ALSPAC）出生队列。产后 8 周时使用爱丁堡产后抑郁量表和 Crown-Crisp 指数分别测量母亲的产后抑郁和焦虑。使用各种基于问卷和访谈的评估方法，在 10-13 岁时测量后代的心理健康结果。使用逻辑回归分析评估产后危险因素与后代心理健康之间的关联，并使用路径分析调查产后因素对青少年后代结局的途径。
有 14054 名母亲报告了产后抑郁信息，13892 名母亲报告了产后焦虑信息，数据可用于分析。逻辑回归分析发现，母亲产后抑郁与 10 岁时后代焦虑显著相关（优势比=1.039，95%置信区间=[1.005, 1.073]，=0.022），母亲产后焦虑与 12/13 岁时后代精神病体验显著相关（优势比=1.042，95%置信区间=[1.008, 1.077]，=0.016）。当我们控制潜在的后代精神病理学重叠时，这些显著关联在应用路径分析后仍然存在。
这些发现表明，产后抑郁的母亲更有可能在 10 岁时使后代出现焦虑，而产后焦虑的母亲更有可能在 12/13 岁时使后代出现精神病体验。我们的研究结果表明，产后焦虑/抑郁与后代心理健康之间存在特定的关联途径，并有助于确定具有产后精神障碍不良后果高易感性的母亲及其后代的重要性。
Zotero 插件