Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50/A, Budapest 1083, Hungary.
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg 69117, Germany.
Database (Oxford). 2022 Mar 2;2022(2022). doi: 10.1093/database/baac007.
The postsynaptic region is the receiving part of the synapse comprising thousands of proteins forming an elaborate and dynamically changing network indispensable for the molecular mechanisms behind fundamental phenomena such as learning and memory. Despite the growing amount of information about individual protein-protein interactions (PPIs) in this network, these data are mostly scattered in the literature or stored in generic databases that are not designed to display aspects that are fundamental to the understanding of postsynaptic functions. To overcome these limitations, we collected postsynaptic PPIs complemented by a high amount of detailed structural and biological information and launched a freely available resource, the Postsynaptic Interaction Database (PSINDB), to make these data and annotations accessible. PSINDB includes tens of thousands of binding regions together with structural features, mediating and regulating the formation of PPIs, annotated with detailed experimental information about each interaction. PSINDB is expected to be useful for various aspects of molecular neurobiology research, from experimental design to network and systems biology-based modeling and analysis of changes in the protein network upon various stimuli. Database URL https://psindb.itk.ppke.hu/.
突触后区域是突触的接收部分，包含数千种蛋白质，形成一个精细且不断变化的网络，对于学习和记忆等基本现象背后的分子机制是必不可少的。尽管关于该网络中单个蛋白质-蛋白质相互作用（PPIs）的信息量在不断增加，但这些数据大多分散在文献中或存储在通用数据库中，这些数据库并非专门用于显示对理解突触后功能至关重要的方面。为了克服这些限制，我们收集了补充大量详细结构和生物学信息的突触后 PPIs，并发布了一个免费的资源，即突触后相互作用数据库（PSINDB），以使这些数据和注释可访问。PSINDB 包含数以万计的结合区域，以及介导和调节 PPIs 形成的结构特征，并对每个相互作用的详细实验信息进行了注释。PSINDB 有望在分子神经生物学研究的各个方面都有用，从实验设计到基于网络和系统生物学的建模和分析，以及各种刺激下蛋白质网络的变化。数据库网址：https://psindb.itk.ppke.hu/。
