突触蛋白质组的统一资源和可配置模型及其在疾病中的作用。

The School of Informatics, University of Edinburgh, Edinburgh, UK.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Sci Rep. 2021 May 11;11(1):9967. doi: 10.1038/s41598-021-88945-7.

Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein-protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.

编码突触蛋白的基因与许多表现出临床共病的神经元紊乱密切相关。我们整合了 58 个已发表的突触蛋白质组数据集，这些数据集描述了超过 8000 种蛋白质，并将它们与直接的蛋白质-蛋白质相互作用和功能元数据结合起来，构建了一个网络资源，揭示了多种紊乱所依赖的共享和独特的蛋白质成分。所有数据都以灵活和可访问的格式提供，以鼓励自定义使用。