Netherlands Comprehensive Cancer Organization (IKNL), Department of Research & Development, Utrecht, the Netherlands; CoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands; Netherlands Association for Palliative Care (PZNL), Utrecht, the Netherlands; Libra Rehabilitation and Audiology, Tilburg, the Netherlands.
Netherlands Comprehensive Cancer Organization (IKNL), Department of Research & Development, Utrecht, the Netherlands; Netherlands Association for Palliative Care (PZNL), Utrecht, the Netherlands.
Eur J Cancer. 2022 Apr;165:125-135. doi: 10.1016/j.ejca.2022.01.039. Epub 2022 Feb 27.
This study aims to assess the quality of life and quality of care as experienced by patients with advanced cancer and their relatives while taking their interdependency into account.
A prospective multicentre observational study (eQuiPe study) was conducted. Quality of life scores (EORTC QLQ-C30) was compared to a matched normative population and logistic regression analyses were conducted to assess the relation between high emotional functioning (EF, measured with the EORTC QLQ-C30) and experienced quality of care (IN-PATSAT32, CQ-index PC).
In total, 1103 (65%) patients and 831 (71%) relatives completed the baseline questionnaire, including 699 unique patient-relative couples. Patients experienced lower EF than the normative population (78 versus 87, p < .001). Compared to patients, relatives reported clinically relevantly lower EF (69 versus 78, p < .001). Being more satisfied with care in general (p < .05) and clarity about the key health-care provider (p < .05) was positively associated with high EF in patients. For relatives, experienced continuity of care (p < .01) and information for the patient (p < .05) were positively associated with high EF. The EF of patients (p < .001) and relatives (p < .001) were positively associated with each other and continuity of care as perceived by relatives was positively associated with high EF in patients (p < .01).
Patients with advanced cancer reported low levels of EF but their relatives reported even lower levels of EF. Experienced integrated organisation and satisfaction with care were positively related to EF. The interdependent relation between patients' and relatives' EF and their care experiences suggests that a family-centred approach can optimise palliative cancer care.
The eQuiPe study is registered as NTR6584 in the Netherlands Trial Register.
本研究旨在评估考虑到患者与家属相互依存关系的情况下，晚期癌症患者及其家属的生活质量和护理质量。
进行了一项前瞻性多中心观察研究（eQuiPe 研究）。比较了生活质量评分（EORTC QLQ-C30）与匹配的正态人群，并进行逻辑回归分析，以评估高情绪功能（EF，用 EORTC QLQ-C30 测量）与所经历的护理质量（IN-PATSAT32，CQ-index PC）之间的关系。
共有 1103 名（65%）患者和 831 名（71%）家属完成了基线问卷，其中包括 699 对独特的患者-家属配对。患者的 EF 低于正态人群（78 比 87，p<0.001）。与患者相比，家属报告的 EF 明显较低（69 比 78，p<0.001）。一般来说，对护理更满意（p<0.05）和对关键医疗保健提供者的了解更清楚（p<0.05）与患者的高 EF 呈正相关。对于家属来说，体验到的护理连续性（p<0.01）和为患者提供的信息（p<0.05）与高 EF 呈正相关。患者（p<0.001）和家属（p<0.001）的 EF 相互正相关，家属感知的护理连续性与患者的高 EF 呈正相关（p<0.01）。
晚期癌症患者报告 EF 水平较低，但他们的家属报告的 EF 水平甚至更低。体验到的综合组织和对护理的满意度与 EF 呈正相关。患者和家属的 EF 及其护理体验的相互依存关系表明，以家庭为中心的方法可以优化姑息治疗癌症护理。
eQuiPe 研究在荷兰临床试验注册中心注册为 NTR6584。
