Stadler Julia, Junker Sigena, Gründl Julia, Fröhlich Sebastian, Beisl Marina, Zöls Susanne, Ritzmann Mathias, Eddicks Matthias, Palzer Andreas, Sehl Julia, Höper Dirk, Unterweger Christine, Ladinig Andrea, Mayer Christian
Klinik für Schweine am Zentrum für Klinische Tiermedizin, Ludwig-Maximilians-Universität München.
Friedrich-Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit.
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2022 Feb;50(1):59-67. doi: 10.1055/a-1729-3677. Epub 2022 Mar 2.
In a fattening farm in southern Germany, paralysis of the hind limbs was observed in 2 age groups (50 kg as well as 60 kg) during a 4 week period. Despite a low morbidity of 3.3 % the majority of the affected animals needed to be euthanized in consequence to the progression of their hind limb paralysis. During pathomorphological examinations of 2 affected fattening pigs severe lymphohistiocytic meningoencephalomyelitis and vasculitis were detected. Immunhistochemistry revealed the presence of Porcine Teschovirus antigen in all parts of the central nervous system as well as in several cell types (neurons, glia cells, endothelial cells, mononuclear cells). Porcine Teschovirus was detected by PCR in spinal cord samples. The subsequently performed phylogenetic analysis PCR revealed a close relation (88 % full genome sequence) to porcine Teschovirus A11 strain "Dresden". Other swine relevant pathogens were excluded by PCR, bacteriologic examination and sequencing. Following a period of 4 weeks no additional cases of hind limb paralysis were observed in the fattening farm.
在德国南部的一个育肥场，在为期4周的时间里，两个年龄组（50公斤和60公斤）的猪出现了后肢麻痹症状。尽管发病率较低，仅为3.3%，但由于后肢麻痹症状的进展，大多数受影响的动物需要实施安乐死。在对2头发病的育肥猪进行病理形态学检查时，发现了严重的淋巴细胞性脑膜脑脊髓炎和血管炎。免疫组织化学显示，在中枢神经系统的所有部位以及几种细胞类型（神经元、神经胶质细胞、内皮细胞、单核细胞）中均存在猪捷申病毒抗原。通过PCR在脊髓样本中检测到了猪捷申病毒。随后进行的系统发育分析PCR显示，与猪捷申病毒A11株“德累斯顿”有密切关系（全基因组序列相似度为88%）。通过PCR、细菌学检查和测序排除了其他与猪相关的病原体。在4周的时间里，育肥场未再观察到后肢麻痹的其他病例。
