Department of Orthopaedics, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 355 Xinqiao Road, Dinghai District, Zhoushan, 316000, Zhejiang, People's Republic of China.
College of Medicine, Shaoxing University, Shaoxing, 312000, Zhejiang, People's Republic of China.
Cell Mol Biol Lett. 2021 Jan 20;26(1):3. doi: 10.1186/s11658-020-00246-5.
Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial-mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.
间充质干细胞（MSCs）具有向肿瘤部位归巢的能力。大量报告表明，它们通过多种机制参与多种促进肿瘤的过程，包括免疫抑制；刺激血管生成；向癌相关成纤维细胞转化；抑制癌细胞凋亡；诱导上皮间质转化（EMT）；增加转移和化疗耐药性。然而，其他研究表明，MSCs 通过抑制血管生成、增加炎症浸润、凋亡和细胞周期停滞，以及抑制 AKT 和 Wnt 信号通路，抑制肿瘤生长。在这篇综述中，我们讨论了 MSCs 对肿瘤进展和转移的支持和抑制作用。我们还讨论了基于 MSC 向肿瘤部位归巢的潜力的癌症治疗策略。
