Hidinger K G, Bake B
Respiration. 1986;50(1):49-56. doi: 10.1159/000194906.
Twelve patients with bronchial asthma participated in a blind, randomized, crossover study comparing the effects of 500 micrograms terbutaline in one inhalation, 125 micrograms in four inhalations taken in rapid succession, and 125 micrograms in four inhalations taken with an intervening time interval of 30 min. There were no significant differences between the three modes of inhalation of 500 micrograms terbutaline in any of the spirometric variables, i.e., 1-second forced expiratory volume, forced vital capacity, and maximal airflows when 50 and 75% of the forced vital capacity was exhaled from the total lung capacity. However, there were neither any significant differences between the levels of bronchodilation reached after administration of 500 micrograms and 2 or 3 X 125 micrograms terbutaline with an intervening time interval of 30 min. The time interval between the divided doses was possibly too long to achieve maximum accumulated effect of the four divided doses.
12名支气管哮喘患者参与了一项双盲、随机、交叉研究，比较了单次吸入500微克特布他林、连续快速吸入4次每次125微克以及间隔30分钟吸入4次每次125微克的效果。在任何肺功能变量方面，即从肺总量呼出50%和75%用力肺活量时的1秒用力呼气量、用力肺活量和最大气流，500微克特布他林的三种吸入方式之间均无显著差异。然而，间隔30分钟给予500微克与2或3×125微克特布他林后达到的支气管扩张水平之间也没有任何显著差异。分次给药之间的时间间隔可能太长，无法实现四次分次给药的最大累积效应。
