Weber R W, Smith J A, Nelson H S
J Allergy Clin Immunol. 1982 Dec;70(6):417-22. doi: 10.1016/0091-6749(82)90003-3.
The peak response and the duration of bronchodilator effect were measured after four inhalations at 20 min intervals of 250 micrograms of aerosolized terbutaline in 13 patients with bronchial asthma. Patients were initially studied after strict avoidance of all adrenergic agents for 2 wk; they were then studied at 2 wk intervals for 12 wk while receiving 500 micrograms of aerosolized terbutaline q.i.d. The initial testing (TI) and the testing at the end of 12 wk (TII) were double blind. Both peak response and duration of action decreased significantly between TI and TII. Cumulative dose-response curves showed that further improvement occurred after each inhalation during TI but that there was significant improvement only after the first inhalation during TII.
对13例支气管哮喘患者每隔20分钟吸入250微克雾化特布他林，共吸入4次后，测量支气管扩张剂效应的峰值反应和持续时间。患者最初在严格避免使用所有肾上腺素能药物2周后进行研究；然后在接受每日4次、每次500微克雾化特布他林治疗的同时，每隔2周进行12周的研究。初始测试（TI）和12周结束时的测试（TII）均为双盲。TI和TII之间的峰值反应和作用持续时间均显著降低。累积剂量-反应曲线显示，TI期间每次吸入后均有进一步改善，但TII期间仅在第一次吸入后有显著改善。
